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ProteomicsH2O2 induced oxidative stress may trigger cellular senescence in retinal photoreceptor cells through modulation of ECM-receptor interaction, oxidative phosphorylation and spliceosome pathways
Photoreceptor cells are highly susceptible to oxidative stress induced damage due to their high metabolic rate. Oxidative stress plays a key role in driving pathological events in several different ocular diseases which lead to retinal degeneration and ultimately blindness. A growing number of studi...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037329 | Pride
Proteomics  photoreceptor  oxidative stress  retina  ecm receptor interaction signaling pathway  cellular senescence. 
ProteomicsMouse Model of Alzheimer’s Disease Demonstrates Differential Effects of Early Pathology on Various Brain Regions
Alzheimer’s disease (AD) is a chronic ageing related neurodegenerative disease which is characterized by loss of synapses and neurons in the vulnerable brain regions. Expression perturbations of amyloid β (Aβ) and tau protein in the brain are two hallmarks of AD. Aβ is abnormally generated from amyl...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD019192 | Pride
Proteomics Hippocampus Alzheimer’s disease Cerebellum Amyloid beta Cortex App/ps1 
ProteomicsFunctional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement
We showed that with genetic manipulation as Pten/Socs3 knockout (KO), CNTF overexpression and Lipin1 knockdown (PSCL), RGCs could regenerate and reinnervate into OPN nuclei after pre-OPN optic tract injury. We then performed single-cell RNA sequencing on OPN-projecting retinal ganglion cells and pro...
ORGANISM(S): Mus Musculus 
2024-05-25 | PXD052573 |
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