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UHRF1 is a chromatin-binding protein essential for maintaining DNA methylation and histone modification states, yet its integrated role in vivo remains incompletely understood. To define its function, we generated conditional Uhrf1 knockout embryonic stem cells (ESCs) and embryos. Uhrf1⁻/⁻ ESCs exhi...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-17 | PXD084341 | Pride
The SARS-CoV-2 Delta variant is more contagious than WT and causes severe symptoms.To understand the elevated fusogenicity of Delta, we used LC-MS/MS to characterize the site specific N-linked glycan of spike protein in SARS-CoV-2 Delta variant virions.The glycan analysis revealed increased oligoman...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2023-05-10 | PXD033342 | Pride
Chronic heart failure (CHF), with whether reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), is the end-stage of various cardiovascular diseases and severely affects the patients’ lifespan. There has been no effective drugs to improve clinical outcomes for a long time. Sine th...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD029031 | Pride
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