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TranscriptomicsMicroarray analysis of the impact of high glucose on gene expression in cytotoxic T lymphocytes
This dataset of microarray analysis was designed to examine the impact of high glucose-culture on transcriptomics/gene expression in primary human CD8+ T cells. Primary human CD8+ T cells were isolated from peripheral blood mononulcear cells of healthy donors and stimulated with anti-CD3/anti-CD28 a...
ORGANISM(S): Homo sapiens 
2022-02-20 | E-MTAB-11441 | biostudies-arrayexpress
ProteomicsBoth wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development
Millions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in ep...
ORGANISM(S): Homo Sapiens 
PXD020351 |
ProteomicsA Systems biology approach for defining the potential molecular framework of hypereosinophilic syndrome with cutaneous involvement
Hypereosinophilic syndrome (HES) is a rare multisystem disease that predominantly includes skin with severe and persistent itching. A lack of understanding about the pathological condition and mechanism of dermatosis caused by HES hinders its treatment. In the present study, we applied a quantitativ...
ORGANISM(S): Homo Sapiens 
2020-02-18 | PXD015450 |
ProteomicsThe Matrisome Reveals the Characterization of Skin Keloid Microenvironment
Keloids are fibroproliferative dermal tumors of unknown origin that are characterized by the overabundant accumulation of extracellular matrix (ECM) components. The mechanism of keloid formation has remained unclear because of a poor understanding of its molecular basis. In this study, the dermal EC...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD019052 |
ProteomicsComprehensive Proteomic Atlas of Skin Biomatrix Scaffolds Reveals a Supportive Microenvironment for Epidermal Development
Skin is a thin, stratified tissue covering the entire body. It is microscopically defined by layers of epidermal epithelial cells separated from cells in the dermis by a basement membrane (BM), the skin’s extracellular matrix (ECM). The skin’s ECM binds the layers together to form the tissue’s organ...
ORGANISM(S): Sus Scrofa 
PXD014454 |
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
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