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ProteomicsFBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia
Eradicating leukemic stem cells (LSCs) and overcoming tyrosine kinase inhibitor (TKI) resistance is urgent for chronic myeloid leukemia (CML) treatment. We find that F-box protein 3 (FBXO3) is highly upregulated in CD34+ CML stem cells from TKI-resistant patients and identify it as an innovative CML...
ORGANISM(S): Homo sapiens (Human) 
2026-01-25 | PXD073522 | Pride
Tkis resistance Fbxo3 Cml-lscs Dusp9 Chronic myeloid leukemia 
UnknownTranscriptomic profiling of sesame during waterlogging and recovery.
Not available
S-EPMC6794253 | biostudies-literature
UnknownDocosahexaenoic acid enhances hippocampal insulin sensitivity to promote cognitive function of aged rats on a high-fat diet.
Not available
S-EPMC10006543 | biostudies-literature
UnknownEctopic expression of the sesame MYB transcription factor SiMYB305 promotes root growth and modulates ABA-mediated tolerance to drought and salt stresses in Arabidopsis.
Not available
S-EPMC7019004 | biostudies-literature
UnknownConstruction of a high-density genetic map for sesame based on large scale marker development by specific length amplified fragment (SLAF) sequencing.
Not available
S-EPMC3852768 | biostudies-literature
UnknownIllustration of the variation in the content of flavanone rutinosides in various citrus germplasms from genetic and enzymatic perspectives.
Not available
S-EPMC8788359 | biostudies-literature
UnknownSingle-cell biological network inference using a heterogeneous graph transformer.
Not available
S-EPMC9944243 | biostudies-literature
ProteomicsDelaying aging and enhancing repair of the aged CNS myelin by β-NMN requires SIRT2
Myelin aging is a driving force of CNS aging, and age-dependent declined efficiency of remyelination caused by impaired differentiation capacity of aged oligodendrocyte precursor cell (OPC) is a major cause of demyelinated diseases. Revealing how differentiation capacity of aged OPC is affected meta...
ORGANISM(S): Rattus Norvegicus 
2020-10-18 | PXD022046 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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