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TranscriptomicsDiscovery of novel and conserved microRNAs in Spirodela polyrhiza by deep sequencing
MicroRNAs (miRNAs) are a class of small, endogenous non-coding RNAs, which play key roles in a variety of developmental and physiological processes by regulating gene expressions at post-transcriptional or translational levels. The objective of our work was to explore conserved and novel miRNAs in S...
ORGANISM(S): Spirodela polyrhiza 
2014-02-21 | E-GEOD-55208 | biostudies-arrayexpress
ProteomicsProfiling Glutathionylome in CD38-mediated Epithelial-Mesenchymal Transition
We engineered a cell system in which the glutathione synthetase (GS) mutant was expressed that catalyzed the formation of a glutathione analogy from azido-alanine to profile changes of glutathionylome in CD38-overexpressing cells.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032233 | Pride
Cd38 glutathionylome epithelial-mesenchymal transition 
UnknownFXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.
Not available
S-EPMC11659401 | biostudies-literature
UnknownGLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway.
Not available
S-EPMC4621609 | biostudies-literature
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
UnknownA two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers.
Not available
S-EPMC11965372 | biostudies-literature
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
ProteomicsA proteomic view of WT and △ydiV(stm1344) Salmonella Typhimurium in simulated host environment medium
The flagellum provides essential motility in the pathogenic process of Salmonella host invasion. However, flagellin is strongly antigenic and can be recognized by TLR5, resulting in activation of the host immune system to clear the invading pathogen. The presence of flagella also disrupts the integr...
ORGANISM(S): Escherichia coli 
2022-10-12 | PXD035693 | Pride
Differential protein expression  simulated host environment medium  wt and △ydiv 
ProteomicsQuantitative proteomics combine with affinity MS revealed the molecular mechanism of ginsenoside anti-tumor effects
The Tandem Mass Tag (TMT) labeling quantitative proteomics technique acquired 55620 MS/MS spectra that identified 5499 proteins and 3045 modified proteins. Of these identified proteins, 224 differentially expressed proteins and modified proteins were significantly altered in non-small cell lung canc...
ORGANISM(S): Homo Sapiens 
2019-02-17 | PXD020149 |
ProteomicsProteomics data of DMC-treated senescent cells
Three groups of cells, including the control group, the senescent cells group, and the DMC-treated senescent cells group
ORGANISM(S): Homo Sapiens 
2023-11-23 | PXD047192 |
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