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TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
ProteomicsDrug sensitivity, gene dependency and proteogenomic correlates of the spectrum of telomere maintenance mechanisms in cancer cells
Replicative immortality is a hallmark of cancer, driven by activation of telomere maintenance mechanisms (TMM), that is yet to be therapeutically exploited. To expedite discoveries that will enable development of TMM-targeted therapeutics, we have generated a resource of telomere biology metrics for...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD058664 | Pride
Tmm Cancer Proteomics Swath-dia Telomere biology 
TranscriptomicsExpression profiles of primary bone marrow derived mouse macrophages M-bM-^@M-^S untreated and treated with LPS or LPS+PGE
The polarization of macrophages into an anti-inflammatory or regulatory phenotype plays an important role in resolving inflammation. PGE2 regulates macrophage polarization via a PKA dependent pathway. PKA phosphorylates SIKs, inhibiting their ability to phosphorylate CRTC3 in cells. This in turn ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-41833 | biostudies-arrayexpress
TranscriptomicsEffect of dietary immunostimulation in the portals of entry of rainbow trout after LPS challenge
Rainbow trout (Oncorhynchus mykiss) were fed during 4 weeks with either a control diet or an immunostimulant diet and then injected with LPS to investigate the effect of dietary immunostimulation in the portals of entry, intestine and gills, using a salmonid-specific microarray platform enriched wit...
ORGANISM(S): Oncorhynchus mykiss 
2010-06-25 | E-GEOD-12961 | biostudies-arrayexpress
UnknownHDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses.
Not available
S-EPMC3734831 | biostudies-literature
TranscriptomicsMacrophages stimulated with LPS and Poly (I:C)
The aim of the current study was to investigate the response of in vitro differentiated trout macrophages, a primary cell culture system widely used in fish immunology research, to lipopolysaccharide (LPS) and to the analog viral ds(RNA) Poly I:C. To that end we have used a salmonid-specific microar...
ORGANISM(S): Oncorhynchus mykiss 
2010-06-25 | E-GEOD-13197 | biostudies-arrayexpress
TranscriptomicsEffect of dietary immunostimulation in gills and intestine of rainbow trout
The effect of dietary immunostimulation in the portals of entry, intestine and gills, of rainbow trout (Oncorhynchus mykiss), was investigated using a salmonid-specific microarray platform enriched with immune-related genes. IS-diet feeding significantly changed transcriptomic expression profiles: l...
ORGANISM(S): Oncorhynchus mykiss 
2008-03-31 | E-GEOD-10981 | biostudies-arrayexpress
TranscriptomicsEffect of dietary immunostimulation in head kidney and spleen of rainbow trout
The effect of dietary immunostimulation in the immune organs, head kidney and spleen, of rainbow trout (Oncorhynchus mykiss), was investigated using a salmonid-specific microarray platform enriched with immune-related genes. Immunostimulant-diet feeding significantly changed transcriptomic expressio...
ORGANISM(S): Oncorhynchus mykiss 
2008-08-27 | E-GEOD-11949 | biostudies-arrayexpress
TranscriptomicsOligonucleotide microarray for Sparus aurata
This study describes the development and validation of the Aquagenomic Sparus aurata oligonucleotide-microarray (SAQ) based on the Agilent Technology system (eArray) to provide a platform for studies on the gene expression of gilthead seabream. The platform developed used all available public ESTs ...
ORGANISM(S): Sparus aurata 
2011-04-22 | E-GEOD-28610 | biostudies-arrayexpress
TranscriptomicsGene expression based on an oligonucleotide microarray for Dicentrarchus labrax
Fish respond to stressors by means of an array of changes that involve many biological compartments including molecular, cellular, metabolic, physiological and behavioral acclimation. Among these changes, the immune system also experiences significant alterations that are characterized by an inducti...
ORGANISM(S): Dicentrarchus labrax 
2011-04-23 | E-GEOD-28812 | biostudies-arrayexpress
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