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UnknownReconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.
Not available
S-EPMC6772928 | biostudies-literature
UnknownAntibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channels.
Not available
S-EPMC1573614 | biostudies-literature
UnknownPhospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
Not available
S-EPMC2266577 | biostudies-literature
ProteomicsMulti-omic detection of Mycobacterium leprae in archaeological human dental calculus
Mineralised dental plaque (calculus) has proven to be an excellent source of ancient biomolecules. In this study we present a Mycobacterium leprae genome (6.6-fold), the causative agent of leprosy, recovered via shotgun sequencing of 16th century human dental calculus from an individual from Trondhe...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017836 | Pride
Dental calculus Palaeoproteomics 
ProteomicsBarbed bone point chronology reveals an unexpected hiatus in the archaeology of Southern Scandinavia around 10,300 years BP
The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, which has informed prehistoric studies for more than a century. Central to this has been the first recognizably Mesolithic culture, the Maglemose (c. 11,000 - 8,000 BP), first described in 1903 w...
ORGANISM(S): Cervus elaphus (Red deer) Alces alces (Eurasian elk) 
2020-10-13 | PXD018050 | Pride
Palaeoproteomics Lc-ms Maldi-tof Cervids Archaeology Bone points 
UnknownXylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes.
Not available
S-EPMC4156774 | biostudies-literature
ProteomicsThe biomolecular characterisation of an Early Neolithic finger ring from Syltholm, Denmark
We present the analysis of an osseous finger ring from an early Neolithic context in Denmark. To characterise the artefact and identify the raw material used for its manufacture, we performed micro-computed tomography (Micro CT) scanning, zooarchaeology by mass spectrometry (ZooMS) peptide mass fing...
ORGANISM(S): Cervus elaphus (Red deer) 
2020-01-21 | PXD011811 | Pride
Collagen  lc-ms/ms  mass spectrometry  palaeoproteomics  zooarchaeology  zooms 
ProteomicsGenomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)
Recent improvements in the analysis ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and past genetic diversity of our species. Here we present a “multi-omics” study, integrating genomic and proteomic analyses of two post-Las...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD024346 | Pride
Dental calculus Bone Human Sicily Italy Archaeology Lc-ms/ms 
UnknownMetabolic networks for nitrogen utilization in Prevotella ruminicola 23.
Not available
S-EPMC5552732 | biostudies-literature
UnknownLoss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet.
Not available
S-EPMC5665667 | biostudies-literature
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