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ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres
Protein phosphatase magnesium-dependent 1 delta (PPM1D) is involved in termination of the cell cycle checkpoint by counteracting activity of the tumour suppressor protein p53. By dephosphorylating various proteins at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035268 | Pride
Trf2 Dna repair Ppm1d Dna damage response 
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres.
Protein phosphatase magnesium-dependent 1 delta (PPM1D) terminates the cell cycle checkpoint by dephosphorylating the tumour suppressor protein p53. By targeting additional substrates at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. Using proximity biotinylation ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035273 | Pride
Trf2 Shelterin Telomere Phosphorylation Ppm1d phosphatase 
ModelsJaiswal2017 - Cell cycle arrest
Jaiswal2017 - Cell cycle arrest This model is described in the article: ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, L...
2024-09-02 | BIOMD0000000641 | BioModels
TranscriptomicsGene expression profiling by array of human non-transformed RPE-FUCCI (Fluorescent Ubiquitination-based Cell Cycle Indicator) cells
Progression through the cell cycle is driven by cyclin dependent kinases that control gene expression, orchestration of the mitotic spindle and cell division. Here we used a Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) and performed transcriptomic analysis of human non-transformed c...
ORGANISM(S): Homo sapiens 
2021-04-06 | E-MTAB-9626 | biostudies-arrayexpress
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