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ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres.
Protein phosphatase magnesium-dependent 1 delta (PPM1D) terminates the cell cycle checkpoint by dephosphorylating the tumour suppressor protein p53. By targeting additional substrates at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. Using proximity biotinylation ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035273 | Pride
Trf2 Shelterin Telomere Phosphorylation Ppm1d phosphatase 
TranscriptomicsNovel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity
Despite considerable evidence that RNA-binding proteins (RBPs) regulate mRNA transport and local translation in dendrites, roles for axonal RBPs are poorly understood. Here we demonstrate that a nontelomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP that regulates axonal p...
ORGANISM(S): Rattus norvegicus 
2015-11-06 | E-GEOD-72887 | biostudies-arrayexpress
ProteomicsA cell cycle switch in TRF2 controls t-loop dynamics and DNA secondary structure resolution across the genome
Telomere end-protection by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3’ single-stranded telomere end can assemble into a lasso-like t-loop configuration, which has been proposed to safeguard chromosome ends from being r...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014843 | Pride
Trf2 Shelterin Dna repair Cdk Telomeres Cell cycle Genome stability Rtel1 T-loops Phosphatases Dna replication Lc-ms/ms 
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres
Protein phosphatase magnesium-dependent 1 delta (PPM1D) is involved in termination of the cell cycle checkpoint by counteracting activity of the tumour suppressor protein p53. By dephosphorylating various proteins at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035268 | Pride
Trf2 Dna repair Ppm1d Dna damage response 
GenomicsTaf7l cooperates with Trf2 to regulate spermiogenesis
Taf7l (a paralogue of Taf7) and Trf2 (a TBP-related protein) are components of the core promoter complex required for gene/tissue-specific transcription of protein-coding genes by RNA polymerase II. Previous studies reported that Taf7l knockout mice exhibit structurally abnormal sperm, reduced sperm...
ORGANISM(S): Mus musculus 
2013-09-29 | E-GEOD-50807 | biostudies-arrayexpress
GenomicsGenome-wide localization of Trf2 and TBP in Drosophila embryos
Here we use ChIP-seq in Drosophila embryos to determine the genome-wide binding pattern of TBP and Trf2 using two different antibodies for each factor. ChIP-seq using anti-Trf2 and anti-TBP antibodies in Drosophila embryos
ORGANISM(S): Drosophila melanogaster 
2014-06-04 | E-GEOD-52029 | biostudies-arrayexpress
TranscriptomicsGene expression data from type II pneumocytes from adult mice with and without Trf2
Gas exchange in the mammalian lung occurs in the alveolar sacs lined by epithelial cells that form a barrier allowing effective oxygen diffusion. Telomere syndromes have their most common manifestation in degenerative disease of the alveoli, both pulmonary fibrosis and emphysema. We tested the rol...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-56892 | biostudies-arrayexpress
GenomicsRNA-Seq in senescent cells with restored levels of TRF2
RNA-Seq in senescent cells with restored levels of TRF2
PRJNA673412 | ENA
GenomicsTRF2-ChipSeq in post mitotic cells
We report the TRF2 binding sites in post mitotic mammalian cells under TRF2 (protein level) modulation. By obtaining sequences from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of differentiated muscle cells (myotubes). Importantly we find that TRF2 levels are corr...
ORGANISM(S): Homo sapiens 
2017-10-17 | GSE88983 | GEO
GenomicsTRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer.
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer.
PRJNA771716 | ENA
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