Shelterin - OmicsDI

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A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening, molecula...

ORGANISM(S): Homo sapiens (Human)

2025-01-28 | PXD043281 | Pride

Identification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1

Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we rep...

ORGANISM(S): Homo sapiens (Human)

2019-07-19 | PXD011356 | Pride

Trf2 Shelterin Dj1 Pgk1 Telomere Stress

Structural Basis for Shelterin Bridge Assembly.

Not available

S-EPMC5698806 | biostudies-literature

The evolution of metazoan shelterin.

Not available

S-EPMC8653790 | biostudies-literature

In vivo stoichiometry of shelterin components.

Not available

S-EPMC2801271 | biostudies-literature