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TranscriptomicsHigh-througput sequencing of the rtel1 mutant
RNA sequencing performed on the root tips of rtel1 mutants and Col-0
ORGANISM(S): Arabidopsis thaliana 
2016-09-01 | E-MTAB-2943 | biostudies-arrayexpress
GenomicsHigh-througput sequencing of the rtel1 mutant
High-througput sequencing of the rtel1 mutant
PRJEB7299 | ENA
GenomicsRTEL1 is involved in transcriptional gene silencing and inhibition of heterochromatic DNA methylation
RTEL1 is involved in transcriptional gene silencing and inhibition of heterochromatic DNA methylation
PRJNA811184 | ENA
GenomicsImpaired synthesis of both telomere strands and adaptive TERT reduction in RTEL1 ATPase-dead cells
Impaired synthesis of both telomere strands and adaptive TERT reduction in RTEL1 ATPase-dead cells
PRJNA1496430 | ENA
TranscriptomicsImpaired synthesis of both telomere strands and adaptive TERT reduction in RTEL1 ATPase-dead cells
Regulator of Telomere Elongation Helicase 1 (RTEL1) plays a critical role in telomere replication by disassembling DNA secondary structures such as G-quadruplexes and telomeric loops (T-loops). However, its precise mechanism remains unclear. Previously, we generated HeLa cells homozygous for ATPase-...
ORGANISM(S): Homo sapiens 
2026-07-24 | GSE338949 | GEO
UnknownRTEL1 inhibits trinucleotide repeat expansions and fragility.
Not available
S-EPMC5783307 | biostudies-literature
TranscriptomicsRTEL1 is involved in transcriptional gene silencing and inhibition of heterochromatic DNA methylation
Transcriptional gene silencing is an essential mechanism for controlling the expression of genes and transposable elements (TEs) and is commonly associated with high levels of DNA methylation. Thus, release of silencing is frequently observed in mutants for genes involved in DNA methylation maintena...
ORGANISM(S): Arabidopsis thaliana 
2023-07-04 | GSE197614 | GEO
ProteomicsA cell cycle switch in TRF2 controls t-loop dynamics and DNA secondary structure resolution across the genome
Telomere end-protection by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3’ single-stranded telomere end can assemble into a lasso-like t-loop configuration, which has been proposed to safeguard chromosome ends from being r...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014843 | Pride
Trf2 Shelterin Dna repair Cdk Telomeres Cell cycle Genome stability Rtel1 T-loops Phosphatases Dna replication Lc-ms/ms 
UnknownRTEL1 influences the abundance and localization of TERRA RNA.
Not available
S-EPMC8140157 | biostudies-literature
UnknownRTEL1 is required for silencing and epigenome stability.
Not available
S-EPMC10484728 | biostudies-literature
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