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ProteomicsSubstrate spectrum of PPM1D in the cellular response to DNA double strand breaks
PPM1D (also known as WIP1) is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) by dephosphorylation of DDR proteins. Amplification of PPM1D gene or gain-of-function mutations are commonly found in cancer. Here, we employed chemical inhibition of PPM1D and quantitative...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD035420 | Pride
Double strand breaks Atm Wip1 Kanadaptin Ppm1d Dna damage 
GenomicsDNA sequencing of human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D
Human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D were exposed to ionising radiation (3 Gy) and subsequently were grown in semisolid media for 8 weeks. Six spheroid clones (RPE-PPM1D-T2-SA clones 1-6) were recovered and then were ...
ORGANISM(S): Homo sapiens 
2024-04-05 | E-MTAB-13923 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D – CLONE 0 AND CLONE 1
Human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D were exposed to ionising radiation (3 Gy) and subsequently were grown in semisolid media for 8 weeks. Six spheroid clones (RPE-PPM1D-T2-SA clones 1-6) were recovered and then were ...
ORGANISM(S): Homo sapiens 
2024-04-05 | E-MTAB-13933 | biostudies-arrayexpress
GenomicsGain-of-function PPM1D mutations attenuate ischemic stroke
Gain-of-function PPM1D mutations attenuate ischemic stroke
PRJNA1252735 | ENA
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres
Protein phosphatase magnesium-dependent 1 delta (PPM1D) is involved in termination of the cell cycle checkpoint by counteracting activity of the tumour suppressor protein p53. By dephosphorylating various proteins at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035268 | Pride
Trf2 Dna repair Ppm1d Dna damage response 
GenomicsSingle-cell-sequencing PPM1D Cyclin E1 cells
PPM1D activity promotes the replication stress caused by cyclin E1 overexpression
PRJEB55698 | ENA
GenomicsRNA sequencing of tumors from PPM1D transgenic mouse model
RNA sequencing of tumors from PPM1D transgenic mouse model
PRJNA662713 | ENA
GenomicsDNA sequencing of human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D
DNA sequencing of human nontransformed retinal pigment epithelia RPE-PPM1D-T2 cells carrying a truncating mutation in exon 6 of the PPM1D
PRJEB74059 | ENA
OtherGain-of-function PPM1D mutations attenuate ischemic stroke
Identification of genetic aberrations in stroke, the second leading cause of death worldwide, is of paramount importance for understanding the disease pathogenesis and generating new therapies. Whole-genome sequencing from 10,241 ischemic stroke patients identified eight patients carrying gain-of-fu...
ORGANISM(S): Mus musculus 
2025-05-31 | GSE295060 | GEO
GenomicsSOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells
PRJNA1005625 | ENA
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