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ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
ProteomicsMS approach assessment and Mad1 phosphopeptide analysis
We evaluated the performance of different popular DDA and DIA MS approaches and applied the most sensitive apporaches to monitor phosphoryation events in Mad1.
ORGANISM(S): Homo sapiens (Human) 
2014-10-31 | PXD000964 | Pride
Human Mad1 Targeted proteomics 
ProteomicsCyclin B1-Cdk1 binds MAD1 and facilitates its release from the nuclear pore complex to ensure a robust Spindle Assembly Checkpoint
How the cell rapidly and completely reorganises its architecture when it divides is a problem that has fascinated for almost 150 years. We now know that the core regulatory machinery is highly conserved in eukaryotes but how these multiple protein kinases, protein phosphatases, and ubiquitin ligases...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD017202 | Pride
Human Ms3 Tmt 
ProteomicsConserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint
Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle checkpoint which regulates the metaphase ...
ORGANISM(S): Cryptococcus neoformans 
2024-05-27 | PXD052327 | Pride
Cryptococcus neoformans Mad2 Mad1 Spindle checkpoint Mps 
UnknownATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint.
Not available
S-EPMC4146412 | biostudies-literature
UnknownMad1 destabilizes p53 by preventing PML from sequestering MDM2.
Not available
S-EPMC6449396 | biostudies-literature
UnknownULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.
Not available
S-EPMC6736072 | biostudies-literature
UnknownMad1 influences interphase nucleoplasm organization and chromatin regulation in Drosophila.
Not available
S-EPMC6223205 | biostudies-literature
UnknownMAD1: Kinetochore Receptors and Catalytic Mechanisms.
Not available
S-EPMC5949338 | biostudies-literature
UnknownMAD1 upregulation sensitizes to inflammation-mediated tumor formation.
Not available
S-EPMC11486420 | biostudies-literature
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