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ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
TranscriptomicsAffymetrix GeneChip® human gene 2.0 ST array analysis of SKOV-3 human ovarian cancer cells following siRNA knockdown of MAD2 or TLR4 compared to cells transfected with scrambled negative control siRNAs.
Both TLR4 and MAD2 are biomarkers associated with paclitaxel resistance in ovarian cancer. Therefore we performed microarray analysis following knockdown of each marker in SKOV-3 cells to gain greater insight into key downstream pathways that these biomarkers activate and also determine any potenti...
ORGANISM(S): Homo sapiens 
2020-12-06 | E-MTAB-8440 | biostudies-arrayexpress
GenomicsMad2 knockdown in RPE-1 cells
Single-cell sequencing of RPE-1 cells with Mad2 knockdown
PRJEB33217 | ENA
TranscriptomicsTranscription profiling of mouse lung tumor tissue from TI-K (CCSP-rtTA;TRE-KrasV12), TI-KM (CCSP-rtTA; TRE-KrasV12; TRE-Mad2), recurrence (TI-KM) or normal lung tissue (CCSP-rtTA) reveals Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal
Inhibition of an initiating oncogene often leads to extensive tumor cell death, a phenomenon known as oncogene addiction. This has led to the search for compounds that specifically target and inhibit oncogenes as anti-cancer agents. Whether chromosomal instability (CIN) generated as a result of dere...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19753 | biostudies-arrayexpress
GenomicsMAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis
MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis
PRJNA1004260 | ENA
ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
ProteomicsConserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint
Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle checkpoint which regulates the metaphase ...
ORGANISM(S): Cryptococcus neoformans 
2024-05-27 | PXD052327 | Pride
Cryptococcus neoformans Mad2 Mad1 Spindle checkpoint Mps 
TranscriptomicsDisruption of FAT10-MAD2 binding inhibits tumor progression
FAT10 interacts with MAD2 and caused tumor progression. The hypothesis tested in the present study was FAT10 induces tumor progression through its binding to MAD2 and Disruption of this binding restored its global gene expression
ORGANISM(S): Homo sapiens 
2014-12-01 | GSE54167 | GEO
UnknownMolecular mechanism of Mad2 conformational conversion promoted by the Mad2-interaction motif of Cdc20.
Not available
S-EPMC11947619 | biostudies-literature
UnknownThe Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching.
Not available
S-EPMC2592820 | biostudies-literature
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