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TranscriptomicsSmall-molecule inhibitor JQ1 effect on multiple myeloma cell lines
Pathologic activation of c-Myc plays a central role in pathogenesis of several neoplasias, including multiple myeloma. However, therapeutic targeting of c-Myc has remained elusive due to its lack of a clear ligand-binding domain. We therefore targeted c-Myc transcriptional function by another means,...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31365 | biostudies-arrayexpress
UnknownSex differences in cancer incidence among solid organ transplant recipients.
Not available
S-EPMC10919340 | biostudies-literature
TranscriptomicsRNA-seq of islet, FACS- sorted CD45+Ly6C-CD11B+CD11C+F4/80+ cells from C57bl6/J male mice that were treated with low dose streptozotocin (STZ) or acetate buffer
The experiment was designed to obtain a broader unbiased view of the changes in islet macrophages following low dose STZ challenge. Mice were purchased from Jackson Laboratory (Bar Harbor, ME). 16-20-week-old C57BL/6J males were given 30 mg/kg STZ or acetate buffer (control) i.p. (intraperitoneal ...
ORGANISM(S): Mus musculus 
2019-11-01 | E-MTAB-7234 | biostudies-arrayexpress
TranscriptomicsLow-dose actinomycin D preferentially disrupts EWS-FLI1DNA binding.
Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma. We used a homogenous proximity assay to screen for compounds that disrupt the binding of EWS-FLI1 to its cognate DNA targets. A number of DNA...
ORGANISM(S): Homo sapiens 
2013-08-26 | E-GEOD-45414 | biostudies-arrayexpress
UnknownGenetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.
Not available
S-EPMC3164911 | biostudies-literature
UnknownGenetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.
Not available
S-EPMC3651307 | biostudies-literature
UnknownGenetic variation in CD83 and risks of cervical and vulvar cancers: a population-based case-control study.
Not available
S-EPMC3727898 | biostudies-literature
UnknownA population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.
Not available
S-EPMC4587291 | biostudies-literature
UnknownGenetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: a population-based case-control study.
Not available
S-EPMC3883910 | biostudies-literature
UnknownNucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.
Not available
S-EPMC3833442 | biostudies-literature
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