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MetabolomicsLarge-scale non-targeted serum metabolomics in the Swedish Twin Registry
The TwinGene project, conducted between 2004 and 2008, is a population-based Swedish study of twins born between 1911 and 1958. The study participants have previously participated in a telephone interview called Screening Across the Lifespan Twin Study, conducted between 1998 and 2002. To be include...
2014-08-30 | MTBLS93 | MetaboLights
UnknownIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effect...
S-EPMC6559955 | biostudies-literature
UnknownA genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences i...
S-EPMC4333218 | biostudies-literature
UnknownPopulation genetic differentiation of height and body mass index across Europe.
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. U...
S-EPMC4984852 | biostudies-literature
MetabolomicsLarge-scale non-targeted serum metabolomics in the Prospective Investigation of the Vasculature in Uppsala Seniors
The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) is a community-based study where all men and women at age 70 living in Uppsala, Sweden were invited to participate in 2001. The 1,016 participants (50% women) have been extensively phenotyped. In March 2006 a reinvesigation ...
2014-08-30 | MTBLS90 | MetaboLights
UnknownGenetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts.

Introduction

Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early young adulthood.

Data and methods

Data from 16 l...
S-EPMC12148285 | biostudies-literature
UnknownAdiposity as a cause of cardiovascular disease: a Mendelian randomization study.

Background

Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods.

Methods

The associations of BMI with ...
S-EPMC4553708 | biostudies-literature
GenomicsWhole Genome Profiling to Detect Schizophrenia Methylation Markers

Schizophrenia (SCZ) is a devastating psychiatric disorder. The aim of this study was to detect DNA methylation (5meC) profiles in whole blood associated with SCZ. The sample consisted of schizophrenia cases and controls selected from national population registers in Sweden. We employed MBD protei...

phs000608.v1.p1 | EGA
UnknownCopy number variation in schizophrenia in Sweden.
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ cases and identified multiple rare recurrent CNVs that increase risk of SCZ although with i...
S-EPMC4271733 | biostudies-literature
UnknownThirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche ...
S-EPMC3140055 | biostudies-literature
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