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ProteomicsHuman platelet detergent resistant membranes proteome
Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surfac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080708 | MassIVE
ProteomicsThe platelet releasate in healthy population and pregancy
Upon activation, platelets release a multitude of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). This PR plays an important role in haemostasis, wound healing and the inflammatory response. We and others have used qualitative/quantitative proteomic approaches to ch...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-29 | MSV000082866 | MassIVE
ProteomicsHuman platelet detergent resistant membranes proteome
Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surfac...
ORGANISM(S): Homo sapiens (Human) 
2016-06-23 | PXD002554 | Pride
Human Platelets Detergent resistant membranes Lc-ms/ms 
ProteomicsComparative proteome of the BeWo and HTR8/SVneo trophoblastic cell lines
Here, we have undertaken comparative label-free quantitative (LFQ) proteomic profiling of the proteins expressed in BeWo and HTR8/SVneo cell lines using a mass spectrometry approach. We have identified 1557 proteins in total. 915 proteins were expressed in both cell lines including various transcrip...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005045 | Pride
Comparative proteomics Label-free quantitation Trophoblastic cell lines. 
ProteomicsThe platelet releasate (PR) in human pregnancy
Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognised importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD009361 | Pride
Platelet releasate Pregnancy Mass spectrometry Platelets Label-free quantitation 
ProteomicsHuman platelet β-catenin interaction proteome
In nucleated cells, β-catenin, the key downstream effector of this pathway, is a dual function protein, regulating the coordination of gene transcription and cell–cell adhesion. The specific role of β-catenin in the anucleate platelet however remains elusive. Here, we performed a label-free quanti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD008130 | Pride
Human Mass spectrometry Label-free quantitation Platelets Β-catenin Co-immunoprecipitation 
ProteomicsExtracellular vesicles in Early preterm neonates and thrombin generation
The aim of the EVENT Study (Extracellular Vesicles in Early preterm Neonates and Thrombin generation) was to characterise the circulating EVs in preterm infants, using multiple EV charac- terisation techniques, during the perinatal adaptation period and compare them to healthy full-term controls.
ORGANISM(S): Homo sapiens (Human) 
2026-01-11 | PXD064962 | Pride
Human Plasma Extracellular vesicles 
GenomicsAssociation studies using the Metabochip array - Samples analysed by the WTCCC (1958 British Birth Cohort (58BC), Hypertension cohort (HT), Type 2 Diabetes Cohort (T2D) and Coronary Artery Disease (CAD) cohort)
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effectiv...
EGAS00000000115 | EGA
GenomicsCAD - samples
WTCCC2 samples from Coronary Artery Disease Cohort
EGAD00010000236 | EGA
Genomics58BC - samples
WTCCC2 samples from 1958 British Birth Cohort
EGAD00010000234 | EGA
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