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MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
TranscriptomicsDynamic transcriptome analysis reveals mRNA synthesis and decay in yeast
To obtain rates of mRNA synthesis and decay in yeast, we established dynamic transcriptome analysis (DTA). DTA combines non-perturbing metabolic RNA labeling with dynamic kinetic modeling. DTA was used to monitor the cellular response to osmotic stress in comparison to the wild type. Genomic occupa...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-01 | E-MTAB-439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of liver from C57BL6 mice transfected with AAV8 vectors expressing either GFP or human macrophage inhibitory factor (MIF) or none (PBS).
MIF is a general mediator of inflammatory responses and is associated with several inflammatory diseases including atherosclerosis. Therefore MIF is currently investigated as a therapeutic target for atherosclerosis. Generation of AAV8 vectors expressing human MIF was initiated to overexpress human ...
ORGANISM(S): Mus musculus 
2013-03-07 | E-MTAB-1019 | biostudies-arrayexpress
TranscriptomicsEffects of miRNA sponge/decoy-mediated reduction of miR-15 family activity on the transcriptome of B cell precursors
A common experimental setup to investigate the function of a microRNA is a â??gain-of-functionâ?? approach, in which the microRNA of interest is overexpressed to analyze its impact on a given process. However, a major drawback of this technique is that microRNAs, when expressed significantly above e...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-72767 | biostudies-arrayexpress
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
TranscriptomicsGenes differentially expressed between Bmi1-overexpressing and empty vector control neural stem/progenitor cells
Neural stem/progenitor cells were isolated from the lateral ventricle wall of 4-6 week-old CD1 mice and grown as neurospheres under low density culture conditions. Test cells were transduced with bicistronic retroviral constructs for the over-expression of Bmi1 together with eGFP, and control cells ...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-70451 | biostudies-arrayexpress
TranscriptomicsEffects of miR-125b expression on the transcriptome of B cell precursors
Here, we have screened a miRNA expression library in a pre-B cell expression system to identify miRNAs with a potential oncogenic activity in early lymphocytes. We show that miR-125b is sufficient to transform B cell precursors in vitro as defined by growth factor independence, and demonstrate that ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-59994 | biostudies-arrayexpress
TranscriptomicsBoolean modeling reveals the necessity of transcriptional regulation for bistablity in PC12 Cell Differentiation
The nerve growth factor NGF has been shown to cause cell fate decisions towards either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to ...
ORGANISM(S): Rattus norvegicus 
2016-03-23 | E-GEOD-74327 | biostudies-arrayexpress
UnknownComputer-assisted mitotic count using a deep learning-based algorithm improves interobserver reproducibility and accuracy.
Not available
S-EPMC8928234 | biostudies-literature
TranscriptomicsMicroarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Bone is the most frequent site of metastasis in prostate cancer (PCa) and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow (BM) prior to surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This promp...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-59631 | biostudies-arrayexpress
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