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TranscriptomicsMicroarray expression profiling of NKT and MAIT subsets in different organs of B6-MAIT/CAST mice.
MAIT cells (MAITs) represent an abundant T lymphocyte subset with unique specificity for microbial metabolites presented by the MHC-1b molecule, MR1. MAIT conservation along evolution indicates important, non-redundant functions, but their low frequency in mice has hampered their detailed characteri...
ORGANISM(S): Mus musculus 
2018-12-03 | E-MTAB-7133 | biostudies-arrayexpress
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular1
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039785 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular2
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039804 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_monocellular
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039820 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
ProteomicsTranslatome analyses by bio-orthogonal non-canonical amino acid labeling reveal that MR1-activated MAIT cells induce an M1 phenotype and antiviral programming in antigen-presenting monocytes_bicellular 3
MAIT cells are multifunctional innate-like effector cells recognizing bacterial-derived vitamin B metabolites presented by the non-polymorphic MHC class I related-1 molecule (MR1). Activated MAIT cells can exert regulatory, pro-inflammatory, or cytotoxic responses that enable the direct killing of i...
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039810 | Pride
Boncat Mait cell Antiviral Translatome Mr1-mediated mait cell activation M1 macrophage polarization Proteomics 
TranscriptomicsMicroarray expression profiling of MAIT subsets isolated from thymus of B6-MAIT/CAST mice, as compared to single positive CD4 or CD8 conventional T cells.
In mice, contrary to conventional T cells, MAIT cells acquire a memory phenotype in the thymus in relation with Zbtb16 expression (Savage et al., 2008 ; Koay et al., 2016). To define phenotypic transcriptional signatures of MAIT subsets in the thymus, we analyzed by microarray the transcriptome of M...
ORGANISM(S): Mus musculus 
2019-07-01 | E-MTAB-7702 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of MAIT cells from young and aged mice
In this study, we performed single-cell RNA sequencing (scRNA-seq) on MAIT cells extracted from the intestines of young and aged mice. For each age group, MAIT cells from five individual mice were pooled before sequencing.
ORGANISM(S): Mus musculus 
2024-11-26 | E-MTAB-14483 | biostudies-arrayexpress
TranscriptomicsRNA-seq expression profiling of humain MAIT cells in blood and liver as compared to mainstream TCD4+ and TCD8+ cells.
At variance with what is observed in mice, no distinct MAIT1 or MAIT17 subsets exist in human blood, as all MAIT cells express a variety of transcription factors such as Rorgt, Tbet, Eomes and Helios. However, they are also found in tissues in which they have specific effector functions. To determin...
ORGANISM(S): Homo sapiens 
2018-12-03 | E-MTAB-7143 | biostudies-arrayexpress
MetabolomicsMucosal-Associated-Invariant-T (MAIT) cells stimulated with IL-12/IL-12, anti-CD3/CD28 or both for 16 hours
Not available
ORGANISM(S): Homo sapiens 
ST001653 | MetabolomicsWorkbench
TranscriptomicsSingle-Cell Transcriptome Analysis of MAIT Cell Subsets from human normal intestine
Normal adjacent tissues from colorectal cancer patients were collected for MAIT cell sorting. Sorted MAIT cells from seven individual donors were pooled together. Single-cell RNA sequencing libraries were prepared using the Chromium 5' Single Cell Gene Expression Kit (10x Genomics), following the ma...
ORGANISM(S): Homo sapiens 
2024-11-26 | E-MTAB-14482 | biostudies-arrayexpress
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