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ProteomicsGeneration and Characterization of a Conditional Ku70 Knockout Cell Line
In this study we characterize and investigate the effect of the loss of Ku70 protein in a conditional Ku70 knockout TREx-293 cell system. Loss of Ku70 protein levels was directly correlated with a loss of cell viability, supporting the observation that Ku performs an essential role in human cells. I...
ORGANISM(S): Homo sapiens (Human) 
2023-07-27 | PXD036297 | Pride
Ku70 hek293 
ProteomicsGlobal and diGLY enriched proteomes of RanBPM depleted HeLa cells and RanBPM APMS
The human CTLH complex is a newly discovered multi-subunit E3 ligase. At present, only a few of its ubiquitination targets are known. Here, we use proteomic techniques in RanBPM-depleted HeLa cells to identify ubiquitination substrates of the CTLH complex. First, global proteomics determined protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD024872 | Pride
Human Hela Ctlh complex 
ProteomicsQuinone reductase 2-dependent HCT116 proteome
NQO2/QR2 is related to NQO1, a known quionine reductase that functions in detoxicification for cells. NQO2, however, uses a distinct co-substate with uncertain availability in cells and as a result the functions of NQO2 are poorly understood. Here, to gain insight into potential pathways regulated b...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD033944 | Pride
Nq02 Hct116 Qr2 
ProteomicsRanBPM nuclear vs cytoplasmic interactome
Characterizing RanBPM interactors in the nucleus and cytoplasm using subcellular fractionation of HeLa cells and affinity purification mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2022-07-14 | PXD029539 | Pride
Human Apms Ctlh complex 
ProteomicsGID4-dependent proteome and interactome
The CTLH complex is a multi-subunit ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via substrate receptor GID4. Recently, focus has turned to the complex as a potential mediator of targeted protein degradation, but the role GID4-mediated substrate ubiquitylation and proteasom...
ORGANISM(S): Homo sapiens (Human) 
2024-05-16 | PXD038487 | Pride
Human Bioid Lc-ms/ms 
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
Not available
S-EPMC7556338 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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