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TranscriptomicsExpression profiling, MDA-MB-231-luc2 response to GW501516
MDA-MB-231-luc2 cells were treated with the PPARd specific agonist GW501516 and the resulting expression changes profiled.
ORGANISM(S): Homo_sapiens 
2013-06-25 | E-MTAB-1262 | biostudies-arrayexpress
TranscriptomicsPaclitaxel resistant MDA-MB-231 Cells and resensitization with bexarotene treatment
Acquired drug resistance represents a major challenge in chemo-therapy treatment for various types of cancers. We have found that the retinoid X receptor–selective agonist bexarotene (LGD1069, Targretin) was efficacious in treating chemo-resistant cancer cells. The goal of this microarray study w...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-12791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MDA-MB-231 mammary cancer cells conditionally expressing progesterone receptor isoforms PRA and PRB
The progesterone receptor isoforms PRA and PRB are implicated in breast cancer development and metastasis. Expression ratio PRA/PRB is imbalanced in such cancers under the influence of MAPK-dependent extracellular stimuli that strongly impact progesterone-responsiveM- transcriptional regulation. In...
ORGANISM(S): Homo sapiens 
2012-06-11 | E-TABM-1215 | biostudies-arrayexpress
TranscriptomicsGenome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome
The chromosomes of several widely used laboratory derivatives of Streptomyces coelicolor A3(2) were found to have 1.06 Mb inverted repeat sequences at their termini (i.e. long-terminal inverted repeats; L-TIRs), which are 50 times the length of the 22 kb TIRs of the sequenced S. coelicolor strain M1...
ORGANISM(S): Streptomyces coelicolor 
2005-07-26 | E-GEOD-2994 | biostudies-arrayexpress
TranscriptomicsATAC-seq in control compared to ZEB1 knock-down MDA-MB-231 cells
Identification of open chromatin regions in wildtpye, control knock-down (shCtrl) and ZEB1 knock-down (shZEB1) human breast cancer MDA-MB-231 cells by ATAC(Assay for transposable-accessible chromatin)-seq.
ORGANISM(S): Homo sapiens 
2020-07-22 | E-MTAB-8264 | biostudies-arrayexpress
GenomicsChIP-seq for ZEB1 in the human breast cancer cell line MDA-MB-231
Identification of DNA binding sites of the transcription factor ZEB1 in the human breast cancer cell line MDA-MB-231 by chromatin-immunoprecipitation followed by sequencing (ChIP-seq).
ORGANISM(S): Homo sapiens 
2020-07-22 | E-MTAB-8258 | biostudies-arrayexpress
TranscriptomicsAcquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”
Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.
ORGANISM(S): Homo sapiens 
2014-09-01 | E-MEXP-3982 | biostudies-arrayexpress
TranscriptomicsChIPseq of PPARbeta/delta in MDA-MB-231luc cells
Chromatin-immunoprecipitated with antiPPARD and antiRXR antibodies was performed in MDA-MB-231luc1 cells.
ORGANISM(S): Homo_sapiens 
2013-02-26 | E-MTAB-1097 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila
This SuperSeries is composed of the following subset Series: GSE33546: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq] GSE36038: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions ...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36039 | biostudies-arrayexpress
TranscriptomicsFOXA1 actively represses the molecular phenotype of basal breast cancers.
Breast cancer is a heterogeneous disease comprised of at least five major subtypes. Luminal subtype tumors confer a more favourable patient prognosis, which is in part, attributed to the Estrogen Receptor-alpha (ER) positivity and anti-hormone responsiveness of these tumors. Expression of the forkhe...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31003 | biostudies-arrayexpress
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