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TranscriptomicsTranscription profiling of MDA-MB-231 mammary cancer cells conditionally expressing progesterone receptor isoforms PRA and PRB
The progesterone receptor isoforms PRA and PRB are implicated in breast cancer development and metastasis. Expression ratio PRA/PRB is imbalanced in such cancers under the influence of MAPK-dependent extracellular stimuli that strongly impact progesterone-responsiveM- transcriptional regulation. In...
ORGANISM(S): Homo sapiens 
2012-06-11 | E-TABM-1215 | biostudies-arrayexpress
TranscriptomicsGenome plasticity in Streptomyces: identification of 1 Mb TIRs in the S. coelicolor A3(2) chromosome
The chromosomes of several widely used laboratory derivatives of Streptomyces coelicolor A3(2) were found to have 1.06 Mb inverted repeat sequences at their termini (i.e. long-terminal inverted repeats; L-TIRs), which are 50 times the length of the 22 kb TIRs of the sequenced S. coelicolor strain M1...
ORGANISM(S): Streptomyces coelicolor 
2005-07-26 | E-GEOD-2994 | biostudies-arrayexpress
ProteomicsDetermining MELK inhibitor specificity using MIB/MS
The key objectives of this study were to evaluate the selectivity profiles of three MELK inhibitors, 8a, HTH, and OTS, using a cell-based assay, in order to identify a highly selective inhibitor to subsequently investigate MELK function. To this end, we utilized a chemical proteomics approach called...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016022 | Pride
Chemoproteomics Lfq Kinase enrichment 
ProteomicsCompetitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits Glycogen Synthase Kinase 3 Beta and Activates WNT Signaling
The cellular and organismal phenotypic response to a small molecule kinase inhibitor is defined collectively by the inhibitor’s targets and their functions. The selectively of small molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competiti...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-12-07 | PXD006139 | Pride
Polypharmacology Gsk3β Wnt signaling Kinase Chemoproteomics 
TranscriptomicsAcquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”
Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.
ORGANISM(S): Homo sapiens 
2014-09-01 | E-MEXP-3982 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila
This SuperSeries is composed of the following subset Series: GSE33546: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq] GSE36038: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions ...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36039 | biostudies-arrayexpress
ProteomicsMIB/MS determines SCH772984 is a selective ERK1/2 inhibitor in pancreatic cancer cells
Mutational activation of the KRAS oncogene is a major genetic driver of pancreatic ductal adenocarcinoma (PDAC) growth. KRAS-dependent PDAC growth is mediated primarily through persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade, one of the most extensively studi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD043585 | Pride
Erk Mib/ms Kinases Pancreatic cancer 
TranscriptomicsFOXA1 actively represses the molecular phenotype of basal breast cancers.
Breast cancer is a heterogeneous disease comprised of at least five major subtypes. Luminal subtype tumors confer a more favourable patient prognosis, which is in part, attributed to the Estrogen Receptor-alpha (ER) positivity and anti-hormone responsiveness of these tumors. Expression of the forkhe...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31003 | biostudies-arrayexpress
ProteomicsIL7R mutational activation can initiate Ph-like and PAX5 P80R precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological level...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD017147 | Pride
Acute lymphoblastic leukemia B cells 
TranscriptomicsThe role of PIWIL4 in breast cancer
PIWI proteins bind to PIWI-interacting RNAs (piRNAs) and play key roles in the biogenesis and functions of piRNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms, and are ectopically expressed in multiple forms of cancer...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-78238 | biostudies-arrayexpress
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