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MetabolomicsSpatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

Spatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

2025-11-26 | MTBLS12782 | MetaboLights
ProteomicsMALDI-MSI-guided LCM-MS: Advancing spatial multi-omics in mouse brain tissue
Spatial multi-omics involves the analysis of biomolecules such as proteome, metabolome, and lipidome within their native spatial context in tissues or cells. This approach provides a comprehensive understanding of biomolecular networks in specific biological environments. Mass spectrometry imaging (...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD060073 | Pride
Lcm-ms Spatial omics Maldi-msi 
ProteomicsIntegration of Multiple Spatial Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer
This project introduces a spatial multi-omics (SMOx) pipeline integrating MALDI-2 mass spectrometry imaging (MSI) with Visium spatial transcriptomics (ST) and single-nucleus RNA sequencing (snRNA-seq) to investigate molecular heterogeneity in human prostate cancer (PCa). MALDI-2 MSI was used to map ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD070149 | Pride
Human tissue Prostate cancer Maldi Msi Multi-omics 
UnknownUnveiling the regulatory mechanisms of nodules development and quality formation in Panax notoginseng using multi-omics and MALDI-MSI.
Not available
S-EPMC11954826 | biostudies-literature
UnknownOne section, two worlds: single-cell integration of MALDI-MSI and spatial transcriptomics on the same single tissue section.
Not available
S-EPMC12663239 | biostudies-literature
UnknownExploring 6-aza-2-Thiothymine as a MALDI-MSI Matrix for Spatial Lipidomics of Formalin-Fixed Paraffin-Embedded Clinical Samples.
Not available
S-EPMC12388131 | biostudies-literature
ProteomicsHeterogeneity Assessment and Protein Pathway Prediction via Spatial Lipidomic and Proteomic Correlation: Advancing Dry Proteomics concept for Human Glioblastoma Prognosis
Prediction of proteins and associated biological pathways from lipid analyses via MALDI MSI is a pressing chal-lenge. We introduced "dry proteomics," using MALDI MSI to validate spatial localization of identified optimal clusters in lipid or protein imaging. Consistent cluster appearance across omic...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD054488 | Pride
Spatial proteomics Heterogeneity Dry proteomics Machine learn-ing Glioblastoma prognosis. Cluster estimation Maldi msi multi-omics 
ProteomicsSpatial multi-omics in skeletal muscle unravel complex myofiber architecture
Spatial distribution of metabolites and phospholipids in murine tibialis anterior (TA) muscles.
ORGANISM(S): Mus musculus (Mouse) 
2024-09-27 | PXD048809 | Pride
Metabolomics Skeletal muscle Fiber type 
ProteomicsIntegrated Mass Spectrometry Imaging and Omics Workflows on the Same Tissue Section Using Parafilm-Assisted Microdissection
In this work, we demonstrate the use of grid-aided, parafilm-assisted microdissection to perform MALDI MS imaging and shotgun proteomics and metabolomics in a combined workflow and using only a single tissue section. The grid is generated by microspotting of acid dye 25 using a piezoelectric microsp...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-03-20 | PXD005345 | Pride
Proteomics Lipidomics Maldi ms imaging Parafilm-assisted microdissection 
MetabolomicsSpatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies

Recent developments in spatially resolved -omics have enabled the joint study of gene expression, metabolite levels and tissue morphology, offering greater insights into biological pathways. Integrating these modalities from matched tissue sections to probe spatially-coordinated processes, howeve...

2025-12-03 | MTBLS13445 | MetaboLights
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