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ProteomicsMALDI-MSI-guided LCM-MS: Advancing spatial multi-omics in mouse brain tissue
Spatial multi-omics involves the analysis of biomolecules such as proteome, metabolome, and lipidome within their native spatial context in tissues or cells. This approach provides a comprehensive understanding of biomolecular networks in specific biological environments. Mass spectrometry imaging (...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD060073 | Pride
Lcm-ms Spatial omics Maldi-msi 
ProteomicsLaser capture microdissection-capillary zone electrophoresis-tandem mass spectrometry (LCM-CZE-MS/MS) for spatially resolved top-down proteomics: a pilot study of zebrafish brain
Mass spectrometry (MS)-based spatially resolved top-down proteomics (TDP) of tissues is crucial for understanding the roles played by microenvironmental heterogeneity in the biological functions of organs and for discovering new proteoform biomarkers of diseases. There are few published spatially re...
ORGANISM(S): zebrafish metagenome 
2023-03-11 | PXD027741 | Pride
Spatially resolved top-down proteomics  capillary zone electrophoresis-tandem mass spectrometry  laser capture microdissection  zebrafish brain  proteoform  high sensitivity  neuropeptide hormone activity  motor activity 
UnknownLaser capture microdissection-capillary zone electrophoresis-tandem mass spectrometry (LCM-CZE-MS/MS) for spatially resolved top-down proteomics: a pilot study of zebrafish brain.
Not available
S-EPMC9066772 | biostudies-literature
UnknownLaser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues.
Not available
S-EPMC7302139 | biostudies-literature
ProteomicsRobust collection and processing for label-free single voxel proteomics
With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. However, such bulk measurement lacks spatial resolution and obscures important tissue heterogeneity, which make it impossible for proteome mapping of tissue microenvironment. Here...
ORGANISM(S): Homo Sapiens (human) 
2024-11-01 | PXD045043 | JPOST Repository
ProteomicsProteomics on formalin-fixed and stained laser-capure microdissected human lung sections
A broad range of tissues have been examined by microscopy following a process of formalin fixation, paraffin embedment, sectioning and staining. Haematoxylin and eosin (H&E) – which respectively stain nuclei blue and other cellular and stromal material pink – are routinely used for clinical diagnosi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014762 | Pride
Lung Human Laser-capture Dissection Spatial proteomics Fixed 
ProteomicsMALDI informed microdissected airway proteomics
After performing MALDI metabolomics analysis, we identified airway regions. On a consecutive slide we used laser capture microdissection (LCM) to cut out regions of interest that had an airway specific signal by MALDI. The samples were prepped using the MicroPOTS protocol (PMID: 33491460) and analyz...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-20 | MSV000090561 | MassIVE
ProteomicsQuantitative proteomics of coeliac gut during 14-day gluten challenge: low-level baseline inflammation despite clinical and histological normality predicts subsequent response
Coeliac disease is a small intestinal disorder caused by an abarrent immune response towards dietary gluten due to activation of pro-inflammatory gluten specific CD4+ T cells. Histological evaluation and classification of gluten induced musosal changes is part of the diagnostic work up. of adults. ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD018977 | Pride
Coeliac disese Lc-msms Proteomics Human intestine Ffpe Laser capture microdissection Gluten challenge 
ProteomicsLaser Capture Microdissection of Normal Kidney Biopsy Glomeruli and Tubulointerstitium Characterized by LC-MS/MS
The Kidney Precision Medicine Project (KPMP) is funded by the NIDDK for "the purpose of understanding and finding new ways to treat chronic kidney disease and acute kidney injury. " To accomplish this goal, the KPMP chose several technologies to successfully deliver their goals....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-13 | MSV000089251 | MassIVE
TranscriptomicsFasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival
Short-term fasting protects mice from lethal doses of chemotherapy through undetermined mechanisms. Herein, we demonstrate that fasting preserves small intestinal (SI) architecture by maintaining SI stem cell viability and SI barrier function following exposure to high-dose etoposide. Nearly all SI ...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-72122 | biostudies-arrayexpress
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