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MetabolomicsFunctional Remodeling of the Gut Microbiome and Metabolome in Primary Idiopathic Male Infertility

Abstract

Background: Primary idiopathic male infertility (PIMI) is a complex condition with unclear biological mechanisms. Increasing evidence indicates that gut microbiome-derived functional and metabolic alterations can influence host physiological processes, yet microbiome-associated fun...

2026-04-07 | MTBLS13886 | MetaboLights
MetabolomicsChronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

The study investigates the effects of 6PPDQ on male fertility in adult mice. The findings of this study are essential as the effects of low-dose environmental factors of 6PPDQ on adult male infertility are unclear, with the increasing in male infertility. The results suggest that 6PPDQ adversely ...

2025-07-14 | MTBLS9432 | MetaboLights
TranscriptomicsSystematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility
Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infe...
ORGANISM(S): Homo sapiens 
2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress
TranscriptomicsArray-based DNA methylation profiling in male infertility reveals allele-specific DNA methylation in PIWIL1 and PIWIL2
Array-based DNA methylation profiling in peripheral blood leukocytes of 30 infertile men with impaired spermatogenesis as compared to 10 fertile men using the Illumina Infinium HumanMethylation 450k Bead Chip reveald 471 CpG sites (287 genes) to be differentially methylated between both groups. Thes...
ORGANISM(S): Homo sapiens 
2014-02-16 | E-GEOD-51245 | biostudies-arrayexpress
ProteomicsTowards understanding male infertility after spinal cord injury through quantitative proteomics
The study of male infertility after spinal cord injury (SCI) has enhanced the understanding of seminal plasma (SP) as an important regulator of spermatozoa function. However, the most important factors leading to the diminished sperm motility and viability observed in semen of men with SCI remained ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-01 | PXD002145 | Pride
Anejaculation Human seminal plasma Spinal cord injury Male infertility Quantitative proteomics Lc-ms/ms 
ProteomicsEjaculate samples for male infertility screening
The problem of the male reproductive system has both medical and social importance. It is highlighted that spermatozoa or seminal plasma are suitable samples for proteomic analysis of the male reproductive system. We suggested that the ejaculate could serve as one of the analytic specimens to determ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD046848 | Pride
Proteomic analysis Male infertility Testis-specific proteins Ejaculate Spermatozoa 
ProteomicsNew insights on sperm function in male infertility of unknown origin: proteomics characterization
The global trend on (male)infertility is concerning and the unidentifiable causes in half of the cases demands a better understanding of the molecular, biochemical and metabolic mechanisms as well as the identification of external and internal factors operating behind it, that might help to explain ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD040292 | Pride
Xxxxxxidiopathic male infertility  unexplained male infertility  sperm function  sperm proteomics 
TranscriptomicsComprehensive analysis of genic male sterility-related genes in Brassica rapa using Brassica rapa 300k microarray v2.0
To identify genes associated with genic male sterility (GMS) that could be useful for hybrid breeding in Chinese cabbage (Brassica rapa ssp. pekinensis), floral bud transcriptome analysis was carried out using a B. rapa microarray with 300,000 probes (Br300K). Among 47,548 clones deposited on a Br30...
ORGANISM(S): Brassica rapa subsp. pekinensis 
2013-10-22 | E-GEOD-47665 | biostudies-arrayexpress
ProteomicsIdentification of a damaging variant rs35033974 associated with idiopathic male infertility through degradation of TEX101 protein and its transient interactome
Human TEX101 is a testis-specific cell membrane protein expressed exclusively in male germ cells and a validated biomarker of male infertility. TEX101 was suggested to function as a cell surface chaperone of numerous proteins involved in sperm migration and sperm-egg interaction. However, the precis...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-02 | MSV000096278 | MassIVE
GenomicsGenetics of Male Infertility Initiative (GEMINI)
Genetics of Male Infertility Initiative (GEMINI)
PRJNA901611 | ENA
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