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ProteomicsRespiratory and C4-photosynthetic NAD-malic enzyme coexist in bundle sheath cells mitochondria and evolved via association of differentially adapted subunits
In Cleomaceae species, NAD-malic enzyme (NAD-ME) was independently co-opted to participate in C4 photosynthesis. In C4 Cleome species, all NAD-ME genes (NAD-MEα, -ß1 and -ß2) were affected by C4 evolution and are expressed at higher levels than their C3 orthologs in Tarenaya hassleriana. In C3 Cleom...
ORGANISM(S): Gynandropsis gynandra Cleome angustifolia Tarenaya hassleriana 
2021-11-30 | PXD026547 | Pride
Cleomaceae C4-photosynthesis Photosynthesis Respiration Nad-malic enzyme Plant 
MetabolomicsEvidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function
Not available
ORGANISM(S): Escherichia coli 
ST000900 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-sequencing was performed to investigate the role of the Candida albicans protein kinase Sky2 in metabolic adaptation to alternative carbon sources. The Candida albicans wildtype strain SC5314 and a sky2 deletion mutant were grown in medium with either glucose (3h), malic acid (6h) or succinic ac...
ORGANISM(S): Candida albicans 
2026-04-01 | E-MTAB-16222 | biostudies-arrayexpress
TranscriptomicsGenomic deletion of malic enzyme 2 confers collateral lethality in pancreas cancer
Comparison of malic enzyme 3 (ME3) depleted vs non-depleted xenograft tumors. ME3 is an isoform of ME2.
ORGANISM(S): Homo sapiens 
2017-08-22 | GSE80411 | GEO
ProteomicsMalic enzyme 2 mediates fumarate signaling to regulate mitochondrial biogenesis
Mitochondria have an independent genome (mtDNA) and protein synthesis machinery that coordinately activate for mitochondrial generation. Here, we report that Krebs cycle intermediate, fumarate, connects metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Proteomic profiling of ME2-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-28 | MSV000086778 | MassIVE
TranscriptomicsLiver gene expression profiling of cytosolic malic enzyme knockout mice
Cytosolic malic enzyme (Me1) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of Me1 knockout mice (Me1-/-) and their littermate wild-type (wt) controls...
ORGANISM(S): Mus musculus 
2009-03-08 | GSE11992 | GEO
TranscriptomicsLiver gene expression profiling of cytosolic malic enzyme knockout mice
Cytosolic malic enzyme (Me1) was predicted as a causal gene for abdominal using a novel statistical method named LCMS (Schadt et al., 2005, Nature Genetics). In order to validate this prediction, we profiled the liver tissues of Me1 knockout mice (Me1-/-) and their littermate wild-type (wt) controls...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11992 | biostudies-arrayexpress
TranscriptomicsMetabolic imbalance caused by loss of malic enzymes in the legume endosymbiont Sinorhizobium meliloti
Malic enzymes decarboxylate the tricarboxylic acid (TCA) cycle intermediate malate to the glycolytic end-product pyruvate and are well positioned to regulate metabolic flux in central carbon metabolism. The bacterium Sinorhizobium meliloti has a NAD(P)-malic enzyme (DME) and a NADP-malic enzyme (TM...
ORGANISM(S): Sinorhizobium meliloti 
2015-07-25 | E-GEOD-71308 | biostudies-arrayexpress
UnknownRequirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway.
Not available
S-EPMC2798650 | biostudies-literature
GenomicsαKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell cycle progression
αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell cycle progression
PRJNA915613 | ENA
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