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ProteomicsProteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Follicles of polycystic ovaries (PCO) often become arrested in early antral stages at around 3 to 11 mm in diameter. The condition disturbs dominant follicle selection and may result in altered ovulation and anovulation. During the growth and development of human follicles, the follicular fluid (FF)...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD031485 | Pride
Proteomics Oocyte maturation. Small antral follicles Follicular fluid 
ProteomicsA pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort
Testosterone deficiency afflicts approximately 30% of men aged from 40-89 years. It is associated with type 2 diabetes, metabolic syndrome and cardiovascular disease. However, the causality of the relationship between low testosterone and metabolic diseases is unclear. We have analysed plasma sampl...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD016096 | Pride
Testosterone Mass spectrometry Proteomcis 
ProteomicsProgressive Changes in Human Follicular Fluid Composition over the Course of Ovulation: Quantitative Proteomic Analyses.
The composition of follicular fluid reflects crucial paracrine signalling between granulosa- and theca cells and the oocyte. Dynamic changes in the protein composition of human follicular fluid across multiple time points in the period where final meiotic maturation and release of the oocyte take pl...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD012561 | Pride
Ovulation Human Oocyte maturation Follicular fluid Proteome 
ProteomicsProteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Protein composition of human ovarian follicular fluid (FF) constitutes the microenvironment for oocyte development. Several proteomics studies of FF from pre-ovulatory follicles have revealed insights on oocyte maturation, however, there is a lack of knowledge on changes produced at protein levels i...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021338 | Pride
Proteomics Oocyte maturation. Small antral follicles Follicular fluid 
ProteomicsProteome of fluid from human small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Human ovarian follicles develop a fluid-filled antrum when they reach a diameter of around 250 µm. The antrum contains follicular fluid (FF) composed of secretions from cells in the follicle and from circulation. The composition of FF undergoes massive changes in relation to follicular development. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013344 | Pride
Follicles Proteomics Human Folliculogenesis Follicular fluid 
ProteomicsNovel potentially clinically valuable protein markers of androgen activity in humans
Background Testosterone (T) is the main androgen playing a crucial role in regulating the function of both reproductive and non-reproductive organs. Current methods for assessing T levels in humans do not reflect the biological androgenic activity (BAA), which may be important for example in the di...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD024448 | Pride
Testosterone deficiency Proteomics Androgen activity Biomarkers 
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, fractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080282 | MassIVE
ProteomicsA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues, unfractionated approach
Malignant melanoma has currently the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has previously has very limited possibilities to be cured. Recently, several protein kinase inhib...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-23 | MSV000080280 | MassIVE
OtherA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues.
Data from ProteomeXchange, .PXD ID: PXD001724. Experiment: M35_003, file: folder summary. Published as part of PLoS One. 2015 Apr 13;10(4):e0123661 . From the Abstract: {{i}} ... The aim of the present study was to build a protein sequence database in metastatic melanoma, searching for novel, relev...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310019253 | GPMDB
Resource Reanalysis 
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