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Younger age and obesity increase the incidence and rates of metastasis of triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. The tissue microenvironment, specifically the extracellular matrix (ECM), is known to promote tumor invasion and metastasis. We sought to characteri...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-06 | PXD050250 | Pride
Tissue from cleared mammary fat pad and sham-operated controlateral control was removed before and at 10, 15,17, and 19 days of pregnancy. Cleared vs. controlateral tissue was hybridized in dye-swap design to in-house cDNA microarry platform. This design aims to identify factors signaling from the e...
ORGANISM(S): Mus musculus 
It was demonstrated that mice with eIF4E that cannot be activated by phosphorylation (S209A) produced extracellular matrix (ECM) less conducive to breast cancer tumor invasion and metastasis. To examine whether this could in part bedue to differences in the protein composition we analyzed the proteo...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD028953 | Pride
Rat mammary tumors induced by N-methyl-N-nitrosurea (NMU) and normal mammary gland
ORGANISM(S): Rattus norvegicus 
Decoding genome-wide effects of experimental tissue-tissue or cell-cell interactions is important, for example, to better understand tumor-stroma interactions after transplantation (xenografting). Transcriptome analysis of intermixed human and mouse cells has frequently relied on the need to separat...
ORGANISM(S): Homo sapiens 
Apolipoprotein E (APOE) and the low-density lipoprotein receptor (LDLR) play a key role in regulating lipoprotein transport and cholesterol homeostasis. However, their roles in porcine fat deposition and adipose tissue remodelling are not well understood. This study utilised wild-type (WT) and APOE/...
2026-09-09 | MTBLS15330 | MetaboLights
MOLECULAR SIGNATURE OF IN UTERO HYPERTHERMIA ON THE MAMMARY FAT PAD OF NEWBORN HEIFERS
Tissue from cleared mammary fat pad and sham-operated controlateral control was removed before and at 10, 15,17, and 19 days of pregnancy. Cleared vs. controlateral tissue was hybridized in dye-swap design to in-house cDNA microarry platform. This design aims to identify factors signaling from the e...
ORGANISM(S): Mus musculus 
2014-03-31 | GSE50447 | GEO
Bariatric surgery reduces obesity associated breast cancer and enhances response to immunotherapy [Mammary Fat Pad RNA-seq]
Assessment of the effect of nutrition level on transcriptome of mammary gland structural components (parenchyma (PAR) and fat pad (MFP)) and liver in dairy calves mammary gland in dairy calves
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