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ProteomicsFA-SAT ncRNA interactome
FA-SAT is a satellite DNA sequence present and transcribed in many Bilateria species, what may anticipate a conserved and significant function in these genomes. Here we prove that in cat and human cells, FA-SAT satellite transcripts play a nuclear function at the G1 phase of the cell cycle. We ident...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Felis silvestris 
2020-03-19 | PXD010081 | Pride
Fa-sat  satellite dna  non-coding rna  apoptosis  interactome  swath-ms 
ProteomicsOxSWATH applied to in-vitro the characterization of redox state of recombinant DJ-1 proteins
Most of the redox proteomics strategies are focused on the identification and relative quantification of cysteine oxidation changes without considering the variation in the total levels of the proteins. However, the regulation of protein synthesis and protein degradation are also associated with man...
ORGANISM(S): Homo sapiens (Human) 
2019-02-16 | PXD006803 | Pride
Redoxomics  cysteine oxidation  swath-ms  differential alkylation  recombinant dj-1 
ProteomicsDataset of the proteome profiles of sea bass (Dicentrarchus labrax) skin-scale exposed to estradiol and fluoxetine
Contamination of aquatic ecosystems with anthropogenic pollutants, including pharmaceutical drugs, is a major concern worldwide. Fish are particularly at risk of exposure to pollutants but their impacts on mineralized fish tissues, particularly the scales that form a barrier between the fish and the...
ORGANISM(S): Dicentrarchus labrax 
2022-01-11 | PXD020983 | Pride
Swath-ms quantitative proteomics  fish scales  emerging pollutants  antidepressant  estrogen 
ProteomicsProteomic Analysis of Mouse Cerebral Cortex Following Experimental Ischemic Stroke: Identifying Novel Biomarkers of Damage and Repair
Stroke remains a major global health challenge due to its high mortality and significant socioeconomic burden. Despite advances in clinical management, effective diagnostic tools and therapeutic strategies remain limited. This study aimed to identify and expand the repertoire of biomarkers of damage...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-19 | PXD067155 | Pride
Magnetic resonance imaging Mouse cerebral cortex Proteomic analysis Middle cerebral artery occlusion Ischemic injury Gene ontology 
ProteomicsTools for flesh quality and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets
Fresh fish are highly perishable food products and their short shelf-life limits their commercial exploitation, leads to waste and has a negative impact on aquaculture sustainability. New non-thermal food processing methods, such as High pressure (HP), are being investigated to prolong shelf-life wh...
ORGANISM(S): Dicentrarchus labrax 
2019-11-06 | PXD012737 | Pride
European sea bass  fillet  high pressure  metagenomics  proteomics  swath 
ProteomicsChronic stress alters the E/I balance of pyramidal neurons in the infralimbic and Prelimbic cortices
The medial prefrontal cortex (mPFC) is a key brain region involved in controlling working memory, executive function, and self-regulatory behaviours, and its malfunction is a hallmark of several neuropsychiatric disorders such as schizophrenia, depression, and post-traumatic stress disorder. One of ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD047291 | Pride
Infralimbic cortex Chronic stress Prelimbic cortex E/i balance 
ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. Although the changes that occur with ageing in the IVD have been under study, no...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD004922 | Pride
Intervertebral disc (ivd)  extracellular matrix (ecm)  nucleus pulpous (np)  itraq 
ProteomicsMultiomic approaches for thyroid cancer diagnosis
Thyroid cancer is a common endocrine malignancy; however, its diagnosis is not straightforward. The current gold standard for diagnosing thyroid cancer is fine needle aspiration biopsy (FNAB), but when cytological analysis does not provide viable results or samples belong to less defined categories ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035583 | Pride
Mixomics Tissue Swath-ms Proteomics Thyroid cancer Biomarkers 
ProteomicsDeciphering Early Pathogenic Changes in Alzheimer's disease
The aim of the present project is to detect biochemical alterations that can pinpoint specific pathogenic processes at early phases of AD, evaluated in the cerebrospinal fluid, that more closely reflect the pathogenic processes in the brain, and independently of whether an amyloid response was trigg...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD039563 | Pride
Alzheimer's disease  cerebral spinal fluid proteomics 
ProteomicsBone marrow mesenchymal stem cells’ secretome exerts neuroprotective effects in a Parkinson’s disease rat model
Parkinson’s disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014887 | Pride
Neuroprotection Dopamine neurons Secretome Mesenchymal stem cells Parkinson's diasese 
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