Mantle cell lymphoma

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Unknown (1008)
Transcriptomics (541)
Genomics (330)
Clinical (58)
Proteomics (35)
Other (13)
Methylation profiling (3)
Metabolomics (2)
Genomic (1)

Organisms

Homo sapiens (469)
Mus musculus (156)
Rattus norvegicus (28)
Zea mays (8)
Drosophila melanogaster (5)
Arabidopsis thaliana (5)
Oryza sativa (4)
Glycine max (4)
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Caenorhabditis elegans (1)
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Organisms

Homo sapiens (143)
Mus musculus (8)

Repository

biostudies-arrayexpress (436)
ENA (179)
geo (152)
EGA (117)
pride (18)
MassIVE (13)
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Tissue

B cell (10)
Cell culture (6)
Blood (2)
Cell line (1)
Others (1)
Cell suspension culture (1)
Lymph node (1)
Lymphoblast (1)
Mesenchymal cell (1)
Mesenchymal stem cell of Wharton's jelly (1)
Peripheral blood lymphocyte (1)
Peripheral blood mononuclear cell (1)
Permanent cell line cell (1)
Primary cell line cell (1)
Spleen (1)
Whole body (1)

Disease

Oral squamous cell carcinoma (2)
Endometrium adenocarcinoma (1)
Gastric tubular adenocarcinoma (1)
Undifferentiated carcinoma (1)
Amelanotic melanoma (1)
Salivary gland squamous cell carcinoma (1)
Endometrial endometrioid adenocarcinoma, variant with squamous differentiation (1)
Ovarian endometrioid adenocarcinoma (1)
Gliosarcoma (1)
B-cell prolymphocytic leukemia (1)
Childhood acute monocytic leukemia (1)
Mucinous gastric adenocarcinoma (1)
Hereditary thyroid gland medullary carcinoma (1)
Extrarenal rhabdoid tumor (1)
Meningioma (1)
Leiomyoma, epithelioid (1)
Primary effusion lymphoma (1)
Cecum adenocarcinoma (1)
Bronchioloalveolar carcinoma (1)
Adenosquamous lung carcinoma (1)
Pancreatic adenosquamous carcinoma (1)
Laryngeal squamous cell carcinoma (1)
Duodenal adenocarcinoma (1)
Adult B acute lymphoblastic leukemia (1)
Uterine leiomyosarcoma (1)
Endometrial stromal sarcoma (1)
Chronic eosinophilic leukemia (1)
Ampulla of Vater adenocarcinoma (1)
Cutaneous melanoma (1)
Colon carcinoma (1)

Technology Type

Mass Spectrometry (18)
Affinity purification coupled with mass spectrometry proteomics (8)
Shotgun proteomics (7)
Illumina HiSeq 2000 (2)
Mass spectrometry (2)
Gel-based experiment (2)
Illumina HumanMethylation 450K (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
Bottom-up proteomics (1)
Data-dependent acquisition (1)
Data-independent acquisition (1)

Instrument Platform

Illumina HiSeq 2500 (6)
Illumina HiSeq 4000 (6)
DNBSEQ-G400 (2)
Illumina NovaSeq 6000 (2)
Illumina HiSeq 2000 (2)
Orbitrap Eclipse (2)
Orbitrap Fusion Lumos (2)
Q Exactive HF-X (2)
Q Exactive Plus (2)
AB 310 Genetic Analyzer (1)
NuGEN Trio low input RNA-seq (1)
RNeasy Micro Kit (QIAGEN #74004) (1)
PALM Microbeam Rel. 4.9 with RoboMover microscope (Zeiss) (1)
Hybridization oven (1)
None (1)
Agilent scanner (1)
Picopure RNA kit (1)
Life Technology LCM system (1)
G2500A Hewlett Packard (1)
Other (1)
Scanning hardware (1)
NextSeq 2000 (1)
Illumina MiSeq (1)
Instrument (1)
LTQ Orbitrap Elite (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion (1)
Q Exactive (1)
Q Exactive HF (1)
SYNAPT G2-Si (1)

Publication Date

2013 (66)
2010 (64)
2012 (60)
2008 (57)
2014 (54)
2011 (48)
2015 (39)
2016 (26)
2009 (25)
2025 (23)
2021 (22)
2017 (20)
2026 (18)
2022 (16)
2018 (16)
2024 (15)
2019 (15)
2007 (13)
2020 (9)
2023 (8)
2006 (8)
2005 (3)

UNIPROT ID/AC

A0A024R8H9 (1)
A0A024RC46 (1)
A0A075B6P5 (1)
A0A087WTX5 (1)
A0A087WWK8 (1)
A0A087WYL9 (1)
A0A087X130 (1)
A0A087X1V9 (1)
A0A0A0MR66 (1)
A0A0A0MSA7 (1)
A0A0C4DG89 (1)
A0A0C4DGT3 (1)
A0AVK6 (1)
A0FGR8 (1)
A0FGR8-2 (1)
A0FGR8-6 (1)
A2IPI2 (1)
A2RU30 (1)
A5A3E0 (1)
A6NC98 (1)
A6NFI3 (1)
A6NHL2 (1)
A6NHR9 (1)
A6NJJ0 (1)
A6NNZ2 (1)
A8CG34 (1)
A8MPP1 (1)
A8MUU1 (1)
A9IYQ1 (1)
B2RPK0 (1)

CHEBI ID

CHEBI:91061 (1)
CHEBI:15040 (1)
CHEBI:174822 (1)
CHEBI:165842 (1)
CHEBI:18414 (1)
CHEBI:15889 (1)
CHEBI:138533 (1)
CHEBI:73920 (1)
CHEBI:174200 (1)
CHEBI:89015 (1)
CHEBI:166762 (1)
CHEBI:88779 (1)
CHEBI:78226 (1)
CHEBI:132745 (1)
CHEBI:47962 (1)
CHEBI:145669 (1)
CHEBI:15672 (1)
CHEBI:74349 (1)
CHEBI:133343 (1)
CHEBI:15671 (1)
CHEBI:58360 (1)
CHEBI:76451 (1)
CHEBI:73186 (1)
CHEBI:36790 (1)
CHEBI:18067 (1)
CHEBI:78270 (1)
CHEBI:139048 (1)
CHEBI:166465 (1)
CHEBI:12936 (1)
CHEBI:155834 (1)

Metabolite Name

Not applicable (1)

First Public Date

2014 (42)
2025 (23)
2024 (22)
2021 (16)
2026 (13)
2019 (13)
2017 (10)
2023 (8)
2018 (8)
2022 (7)
2020 (6)
2015 (4)
2013 (4)
2016 (3)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study status

Completed (40)
Terminated (11)
Withdrawn (3)
Active, not recruiting (2)
Recruiting (1)
Not yet recruiting (1)

Study type

Transcription profiling by array (328)
Interventional (56)
RNA-seq of coding RNA (38)
Comparative genomic hybridization by array (18)
Transcription profiling by RT-PCR (8)
Other (6)
Unknown experiment type (4)
ChIP-chip by array (4)
ChIP-seq (4)
Methylation profiling by array (4)
Methylation profiling by high throughput sequencing (4)
RNA-seq of non coding RNA (4)
Animal - High-throughput sequencing (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of total RNA (2)
Observational (2)
RNA-seq of non coding RNA from single cells (1)
Differential (1)
Animal - One-color microarray (1)
Human - High-throughput sequencing (1)
Plant - One-color microarray (1)
Human - One-color microarray (1)
Genotyping by array (1)
MicroRNA profiling by array (1)

Release Date

2022 (121)
2021 (116)
2023 (105)
2024 (92)
2012 (91)
2013 (86)
2014 (82)
2010 (77)
2025 (77)
2015 (71)
2020 (69)
2016 (66)
2019 (64)
2011 (64)
2018 (63)
2008 (59)
2017 (57)
2009 (29)
2007 (19)
2026 (16)
2006 (10)
2005 (5)
2002 (3)
2001 (1)
2000 (1)

Lab affiliation

Department of Chemical & Systems Biology, Stanford University, USA (2)
1) CNRS - ITAV USR3505, 31106 Toulouse, France 2) Nova Medical School, CEDOC- Chronic Diseases, 1150-082, Lisboa, Portugal (1)
Center of Molecular and Cellular Oncology, Yale University (1)
Centre Esther Koplowitz (CEK) (1)
Charles University in Prague, Czech Republic (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
Department of Chemical & Systems Biology Stanford University USA (1)
Department of Genetics, Cell Bioliogy, & Anatomy Buckley Lab University of Nebraska Medical Center Omaha, Nebraska United States of America (1)
Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA (1)
Division of Blood Cells and Blood Cancer The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville Victoria, Australia, 3050 (1)
Head of the Department, Proteomics Core (1)
IB USP (1)
Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute, Badalona, Spain (1)
Moffitt Cancer Center (1)
Moffitt Cancer Center Tampa, FL, USA (1)
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41 – UMS 2014 – PLBS, F-59000 Lille, France (1)
Universidade de São Paulo (1)

Location

United States (54)
Italy (5)
Germany (3)
India (2)
Canada (2)
United Kingdom (1)
France (1)

Keyword

Fludarabine (9)
Fludarabine phosphate (9)
Rituximab (9)
Antibodies, Monoclonal (9)
Mycophenolic Acid (8)
Cyclosporine (8)
Cyclosporins (8)
Antibodies (8)
Immunoglobulins (7)
Cyclophosphamide (6)
Antineoplastic Agents, Immunological (6)
Lenalidomide (5)
Etoposide (5)
Etoposide phosphate (5)
Tacrolimus (4)
Vorinostat (4)
Bendamustine Hydrochloride (3)
Busulfan (3)
Gemcitabine (3)
Histone Deacetylase Inhibitors (2)
Bortezomib (2)
Dexamethasone (2)
Methotrexate (2)
Ipilimumab (2)
CDX-1140 (1)
GI Cancer (1)
Celldex (1)
CD40 (1)
CD-40 (1)
Flt3l (1)

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A polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights

The genes regulated by SOX11 in mantle cell lymphoma

The genes regulated by SOX11 in MCL was investigated in MCL cell line Granta 519 by siRNA knock down system. Cells were transfected using the LONZA electroporation system. Results represent cells harvested after 20 hours. Details of the experiment is published in PMID 21124928. Gene expression profi...

ORGANISM(S): Homo sapiens

2010-11-29 | E-GEOD-25621 | biostudies-arrayexpress

Transcription profiling and genotyping of 26 human mantle cell lymphoma samples

Among B-cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 and U133 set), we analysed 26 MCL samples to identify genes relevant to MCL pathogenesis and that could represent new therapeu...

ORGANISM(S): Homo sapiens

2007-06-24 | E-GEOD-4176 | biostudies-arrayexpress

Genome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...

ORGANISM(S): Homo sapiens

2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress

Transcription profiling by array of human indolent mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the gen...

ORGANISM(S): Homo sapiens

2010-03-04 | E-GEOD-16455 | biostudies-arrayexpress

Tumor biopsies from 71 untreated patients with mantle cell lymphoma

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Keywords: lymphochip; MCL; untreated Tumor biopsies from 71 untreated patients with mantle cell lymphoma

ORGANISM(S): Homo sapiens

2010-05-23 | E-GEOD-10793 | biostudies-arrayexpress

Differential Expression of NF-kB target genes in MALT lymphoma with and without chromosome translocation

MALT lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harboring such translocation do not respond to H. pylori eradication, while those without translocation can be...

ORGANISM(S): Homo sapiens

2010-05-31 | E-GEOD-18736 | biostudies-arrayexpress

Transcription profiling of human mantle cell lymphoma cell lines with inhibition of the NMD pathway

Identification of potential tumor suppressor genes using the GINI strategy in Mantle Cell Lymphoma cell lines Experiment Overall Design: Inhibition of the NMD pathway was performed in Mantle Cell Lymphoma cell lines according to a modified protocol previously described (Noensie EN et al Nat Biotechn...

ORGANISM(S): Homo sapiens

2008-06-15 | E-GEOD-6728 | biostudies-arrayexpress

Mantle Cell Lymphoma

Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and...

ORGANISM(S): Homo sapiens

2013-06-25 | E-GEOD-36000 | biostudies-arrayexpress

Clonal heterogeneity of mantle cell lymphoma revealed by array comparative genomic hybridization

The existence of clonal heterogeneity of mantle cell lymphoma based on genomic aberration evaluated by log2 ratio(clinical samples)

ORGANISM(S): Homo sapiens

2012-07-30 | E-MTAB-1076 | biostudies-arrayexpress

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