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TranscriptomicsThe genes regulated by SOX11 in mantle cell lymphoma
The genes regulated by SOX11 in MCL was investigated in MCL cell line Granta 519 by siRNA knock down system. Cells were transfected using the LONZA electroporation system. Results represent cells harvested after 20 hours. Details of the experiment is published in PMID 21124928. Gene expression profi...
ORGANISM(S): Homo sapiens 
2010-11-29 | E-GEOD-25621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and genotyping of 26 human mantle cell lymphoma samples
Among B-cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 and U133 set), we analysed 26 MCL samples to identify genes relevant to MCL pathogenesis and that could represent new therapeu...
ORGANISM(S): Homo sapiens 
2007-06-24 | E-GEOD-4176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human indolent mantle cell lymphoma
Mantle cell lymphoma (MCL) is an aggressive neoplasm with poor outcome. However, some patients have an indolent disease (iMCL) and may not require intensive treatment at initial diagnosis. Diagnostic criteria to recognize these patients are not available. We hypothesized that the analysis of the gen...
ORGANISM(S): Homo sapiens 
2010-03-04 | E-GEOD-16455 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
TranscriptomicsTumor biopsies from 71 untreated patients with mantle cell lymphoma
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Keywords: lymphochip; MCL; untreated Tumor biopsies from 71 untreated patients with mantle cell lymphoma
ORGANISM(S): Homo sapiens 
2010-05-23 | E-GEOD-10793 | biostudies-arrayexpress
TranscriptomicsMantle Cell Lymphoma
Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-36000 | biostudies-arrayexpress
TranscriptomicsHigh resolution ChIP sequencing reveals novel bindings targets and prognostic role for SOX11 in Mantle cell lymphoma (RNA-Seq)
SOX11 (Sex determining region Y-box 11) expression is specific for MCL as compared to other Non-HodgkinM-bM-^@M-^Ys lymphomas. However, the function and direct binding targets of SOX11 in MCL are largely unknown. We used high-resolution ChIP-Seq to identify the direct target genes of SOX11 in a geno...
ORGANISM(S): Homo sapiens 
2014-08-07 | E-GEOD-52148 | biostudies-arrayexpress
TranscriptomicsGene expression of mantle cell lymphoma-initiating cells from primary tumor samples
In this study we compared the expression of 30215 genes in mantle cell lymphoma-initiating cells (MCL-ICs) with mantle cell lymphoma-non-initiating cells (MCL-non-ICs) and B-cells from healthy donor Three samples each of MCL-ICs and MCL-non-ICs were isolated from aphresis of 3 mantle cell lymphoma p...
ORGANISM(S): Homo sapiens 
2014-08-02 | E-GEOD-60023 | biostudies-arrayexpress
TranscriptomicsSOX11 Gene Expression Profiling
The neural transcription factor SOX11 is overexpressed in aggressive lymphoid neoplasms mainly in mantle cell lymphoma (MCL), but its functional role in malignant B-cells is unknown. To identify target genes transcriptionally regulated by SOX11 in malignant lymphoid cells, we have used Gene Expressi...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-34763 | biostudies-arrayexpress
TranscriptomicsExpression data from MALD1 and MCL cases
Patients with conventional mantle cell lymphoma (MCL) show an aggressive clinical behavior. However, cases fulfilling the WHO criteria for MCL, but that remain asymptomatic without treatment, have been reported. In an attempt to understand this heterogeneity, we have compared 17 typical cases of MCL...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-45717 | biostudies-arrayexpress
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