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TranscriptomicsIdentification of direct transcriptional targets of V600EBRAF/MEK in melanoma
A375P melanoma cells were treated with 1uM of the MEK inhibitor PD184352 or 0.4uM of the V600EBRAF inhibitor PLX4720 for 2hr, 6hr and 24hrs. DMSO treatment for 2hr, 6hr and 24hrs serves as the negative control Triplicate experiments were performed for DMSO, PD184352 and PLX4720 treatment at 3 timepo...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17089 | biostudies-arrayexpress
GenomicsMolecular Oncology Group, PICR
Data Access Committee EGAC00001000095
EGAC00001000095 | EGA
TranscriptomicsRestoring PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance
Immune checkpoint inhibitors (ICIs) are a type of cancer treatment that work by targeting molecules on immune cells that can inhibit the immune system's ability to attack cancer cells. One such checkpoint molecule is PD-1, which is found on the surface of T cells (a type of immune cell) and helps to...
ORGANISM(S): Mus musculus 
2023-08-22 | E-MTAB-12872 | biostudies-arrayexpress
Genomicsena-DATASET-PICR-17-03-2014-12:03:29:405-517 - samples
Whole exome sequencing of 41 melanomas and normal DNA from Braf mutant mice: 15 tumours from UV exposed mice, 15 tumours from non-exposed mice and 11 from UV exposed, sunscreen-protected mice.
EGAD00001000775 | EGA
GenomicsWhole Exome Sequencing of cohorts of Mutant Braf mouse model melanoma DNA and germline DNA.
Whole Exome Sequencing of cohorts of Mutant Braf mouse model melanoma DNA and germline DNA. The cohorts are (1) Mutant Braf mouse model melanomas, (2) Mutant Braf mouse model melanomas from UVR exposed mice and (3) Mutant Braf mouse model melanomas from UVR exposed, sunscreen protected mice.
EGAS00001000729 | EGA
Genomicsena-DATASET-PICR-28-07-2014-16:35:04:391-518 - samples
NGS of 10 mucosal melanomas: Whole genome sequencing of 5 mucosal melanomas and matched normal DNA Whole exome sequencing of 5 mucosal melanomas and matched normal DNA
EGAD00001000945 | EGA
GenomicsWhole genome sequencing and whole exome sequencing of mucosal melanoma
We conducted whole genome sequencing of 5 mucosal melanomas and their matched DNA from blood. We conducted whole exome sequencing of a further 5 mucosal melanomas and their matched DNA from blood.
EGAS00001000474 | EGA
UnknownEffect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
Not available
S-EPMC12701713 | biostudies-literature
UnknownRestrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.
Not available
S-EPMC10837004 | biostudies-literature
UnknownSafety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation.
Not available
S-EPMC11249957 | biostudies-literature
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