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TranscriptomicsAntiviral RNA interference in mammalian cells
Plants and invertebrates protect themselves from viruses through RNA interference (RNAi), yet it remains unknown whether this defense mechanism exists in mammals. Antiviral RNAi involves the processing of viral long double-stranded (ds) RNA molecules into small interfering RNAs (siRNAs) by the ribon...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-43153 | biostudies-arrayexpress
TranscriptomicsSKI2 mediates degradation of RISC 5’-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis
A loss-of-function mutant in the SKI2 helicase in Arabidopsis was shown to accumulate 5'-cleavage fragments of several miRNA targets. Small RNAs in ski2 single and ski2/rdr6 double mutants (two biological replicates of each genotype) were next analysed by NGS. The data show that several miRNA target...
ORGANISM(S): Arabidopsis thaliana 
2015-10-20 | E-MTAB-3781 | biostudies-arrayexpress
UnknownA single miR390 targeting event is sufficient for triggering TAS3-tasiRNA biogenesis in Arabidopsis.
Not available
S-EPMC5435969 | biostudies-literature
UnknownCsfG, a sporulation-specific, small non-coding RNA highly conserved in endospore formers.
Not available
S-EPMC3218505 | biostudies-literature
UnknownThe microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner.
Not available
S-EPMC5007330 | biostudies-literature
UnknownExtensive profiling in Arabidopsis reveals abundant polysome-associated 24-nt small RNAs including AGO5-dependent pseudogene-derived siRNAs.
Not available
S-EPMC6800511 | biostudies-literature
UnknownProcessing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins.
Not available
S-EPMC546153 | biostudies-literature
TranscriptomicsReconstructing de novo silencing of an active plant retrotransposon: dynamics, mechanisms, biological implications
In plants, maintenance-methylation mediated by METHYLTRANSFERASE-1 (MET1), siRNA-directed de-novo methylation, and chromatin remodeling by DECREASE IN DNA METHYLATION -1 (DDM1) promote transcriptional gene-silencing of transposable elements (TEs). This process is mostly investigated at steady states...
ORGANISM(S): Arabidopsis thaliana 
2013-07-02 | E-GEOD-43412 | biostudies-arrayexpress
UnknownHydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).
Not available
S-EPMC3252304 | biostudies-literature
UnknownThe mental health toll of conflict-induced violence on teachers: evidence from a longitudinal survey in DRC and Niger.
Not available
S-EPMC12684203 | biostudies-literature
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