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TranscriptomicsAntiviral RNA interference in mammalian cells
Plants and invertebrates protect themselves from viruses through RNA interference (RNAi), yet it remains unknown whether this defense mechanism exists in mammals. Antiviral RNAi involves the processing of viral long double-stranded (ds) RNA molecules into small interfering RNAs (siRNAs) by the ribon...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-43153 | biostudies-arrayexpress
TranscriptomicsSKI2 mediates degradation of RISC 5’-cleavage fragments and prevents secondary siRNA production from miRNA targets in Arabidopsis
A loss-of-function mutant in the SKI2 helicase in Arabidopsis was shown to accumulate 5'-cleavage fragments of several miRNA targets. Small RNAs in ski2 single and ski2/rdr6 double mutants (two biological replicates of each genotype) were next analysed by NGS. The data show that several miRNA target...
ORGANISM(S): Arabidopsis thaliana 
2015-10-20 | E-MTAB-3781 | biostudies-arrayexpress
TranscriptomicsReconstructing de novo silencing of an active plant retrotransposon: dynamics, mechanisms, biological implications
In plants, maintenance-methylation mediated by METHYLTRANSFERASE-1 (MET1), siRNA-directed de-novo methylation, and chromatin remodeling by DECREASE IN DNA METHYLATION -1 (DDM1) promote transcriptional gene-silencing of transposable elements (TEs). This process is mostly investigated at steady states...
ORGANISM(S): Arabidopsis thaliana 
2013-07-02 | E-GEOD-43412 | biostudies-arrayexpress
TranscriptomicsSlicer activity of Arabidopsis AGO1 in siRNA biogenesis and miRNA target decay
Aim of study The objective of these studies was to analyze the implication of slicer activity of AGO1 in the following molecular processes: loading of siRNAs and miRNAs stability of siRNAs and miRNAs formation of RDR6/SGS3-dependent secondary siRNAs decay of mRNAs targeted by miRNAs The stud...
ORGANISM(S): Arabidopsis thaliana 
2016-09-05 | E-MTAB-4529 | biostudies-arrayexpress
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