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ProteomicsAffinity Purification of ISWI chromatin remodeler in Trypanosoma cruzi
Chromatin remodeling is a general mechanism involved in DNA-dependent processes, including gene expression regulation. ISWI ATPase is the catalytic subunit in diverse chromatin remodeling complexes that changing histone–DNA interactions and therefore play a pivotal role in different nuclear processe...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2020-05-22 | PXD017869 | Pride
Affinity purification Iswi Trypanosoma cruzi Lc-ms/ms 
ProteomicsPhosphoproteome and proteome of T. cruzi metacyclogenesis
Trypanosoma cruzi metacyclogenesis is a natural process that occurs inside triatomine insect vector and corresponds to the differentiation of non-infective epimastigotes into infective metacyclic trypomastigotes. Here, centered on LC-MS/MS approach, a large scale phospho (proteome) study was carried...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2017-08-31 | PXD006171 | Pride
Proteomics Metacyclogenesis Phosphorylation Trypanosoma cruzi 
ProteomicsT. brucei MAPKLK1 knockdown - The MAP kinase MAPKLK1 is essential to Trypanosoma brucei proliferation and regulates proteins involved in mRNA metabolism
Pathogenic trypanosomatids have a large number of protein kinases and phosphatases in comparison to other organisms. Moreover, post-translational modifications have key role in the gene expression control in these cells, reinforcing the relevance of the phosphorylation process. Nevertheless little i...
ORGANISM(S): Trypanosoma brucei 
2017-10-17 | PXD006048 | Pride
Map kinase Ltq orbitrap xl etd Trypanosoma brucei 
ProteomicsQuantitative phosphoproteome and proteome analysis emphasize the influence of phosphorylation events during the nutritional stress of Trypanosoma cruzi: the initial moments of in vitro metacyclogenesis
Phosphorylation is an important event in cell signaling that is modulated by kinases and phosphatases. In T. cruzi, the etiological agent of Chagas disease, approximately 2% of the genome comprises protein kinases. This parasite has a heteroxenic life cycle with four different development stages. In...
ORGANISM(S): Trypanosoma cruzi Dm28c 
2019-08-05 | PXD012113 | Pride
Nutritional stress Proteomics Metacyclogenesis Super-silac Phosphoproteomics Trypanosoma cruzi 
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