Trypanosoma cruzi metacyclogenesis is a natural process that occurs inside triatomine insect vector and corresponds to the differentiation of non-infective epimastigotes into infective metacyclic trypomastigotes. Here, centered on LC-MS/MS approach, a large scale phospho (proteome) study was carried...
Evaluation of differential gene expression during the metacyclogenesis process in Trypanosoma cruzi, comparing three stages (epimastigotes, stressed epimastigotes and 24h adhered epimastigotes in differentiation) and using both total and polysomal mRNA.
Phosphorylation is an important event in cell signaling that is modulated by kinases and phosphatases. In T. cruzi, the etiological agent of Chagas disease, approximately 2% of the genome comprises protein kinases. This parasite has a heteroxenic life cycle with four different development stages. In...
