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MetabolomicsLeptin increases hepatic triglyceride export via a vagal mechanism in humans
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain increases very-low-density lipo...
2023-06-07 | MTBLS4231 | MetaboLights
ProteomicsProteome characterisation of SARS-CoV-2 virions derived from different cells/species
The virions of all enveloped viruses, including SARS-CoV-2 are composed of not only known structural viral proteins (S, N, M, E) but also include some SARS-CoV-2 non-structural proteins as well as host cell protein that were accidentally packed into virions. The project aims to identify these protei...
ORGANISM(S): Homo sapiens (Human) Cercopithecus aethiops (Green monkey) (Grivet) 
2024-11-04 | PXD050009 | Pride
Sars-cov-2 Virion 
ProteomicsLarge-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
Chemical modulation of protein function enables a mechanistic understanding of biological circuits and represents the foundation of most medicines. However, despite major efforts over decades of research, around 80% of the human proteome still lack functional ligands. Chemical proteomics allowed the...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD041587 | Pride
Machine learning Bioactive Drug Screening Chemical probe Fragment-protein interaction Fbld Ai Chemical proteomics Ligandability 
ProteomicsBFP pulldown of BFP-NUDT5 HAP1 MTHFD1-K56R cells
We performed BFP pulldowns with BFP-tagged NUDT5 in HAP1 harboring the MTHFD1 K56R mutation to find interactors of NUDT5. We performed the study under various medium conditions, including full IMDM medium (FULL), IMDM with dialysed FBS (DIA) and DIA supplemented with 50µM adenosine to investigate po...
ORGANISM(S): Homo sapiens (Human) 
2025-11-07 | PXD067739 | Pride
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