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TranscriptomicsInterleukin-10-anergized T-cell infusion provides immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Regulatory T cells restore tolerance in preclinical models of immune-mediated diseases and are therefore a promising alternative to conventional immune-suppression for preventing graft-versus-host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Adaptiv...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-21885 | biostudies-arrayexpress
TranscriptomicsRole of PKD2 in TCR-induced transcriptional reprogramming of naïve T cells
Comparison of transcriptional profile of TCR stimulated P14-TCR wild-type and P14-PKD2 null murine lymph node cells Lymph node cells from 3 biological replicates (3 wild-type and 3 PKD2 null mice) were isolated and left unstimulated or stimulated for 4 hours with antigenic peptide (gp33-41) prior to...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33942 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
TranscriptomicsExpression data from P14 TCR cytotoxic T cells overexpressing HDAC7 phosphorylation deficient mutant
The present study reports an unbiased analysis of the cytotoxic T cell serine-threonine phosphoproteome using high resolution mass spectrometry. Approximately 2,000 phosphorylations were identified in CTLs of which approximately 450 were controlled by TCR signaling. A significantly overrepresented g...
ORGANISM(S): Mus musculus 
2011-03-13 | E-GEOD-27092 | biostudies-arrayexpress
TranscriptomicsExpression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated CTL
In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to expl...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26290 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Cilia are ubiquitous cell surface projections that modulate various sensory- and motility based processes and are implicated in a growing number of multi-organ genetic disorders termed ciliopathies. As new components required for cilium biogenesis and function remain unidentified, we sought to furth...
ORGANISM(S): Caenorhabditis elegans 
2011-07-25 | E-GEOD-25633 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi
We examined the extent to which different Trypanosoma cruzi strains induce transcriptomic changes in cultured L6E9 myoblasts 72 hours or 48 hours after infection with four strains of the parasite [Brazil (TCI); Y, CL and Tulahuen (TC II) strains]. Expression of 6,289 distinct fully annotated unigene...
ORGANISM(S): Rattus norvegicus 
2009-09-22 | E-GEOD-18175 | biostudies-arrayexpress
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsTranscription profiling of human invasive breast cancer carcinomas with different histological types and invasive lobular carcinoma
Gene expression array analysis on a series of ten different histological special types of invasive breast carcinomas (tubular, micropapillary, mucinous A, mucinous B, endocrine, apocrine, metaplastic, medullary, adenoid cystic, invasive ductal carcinoma with osteoclastic giant cells) and invasive lo...
ORGANISM(S): Homo sapiens 
2010-08-20 | E-NCMF-3 | biostudies-arrayexpress
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