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ProteomicsThe lysosomal proteome of senescent cells contributes to the senescence-associated secretome
Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age-related diseases. The senescence-associated secretory phenotype (SASP) is considered the main pathological feature of senescent cells, however, little is known about the mechanism of secretion of SAS...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD022492 | Pride
Lysosomes Senescence Macroautophagy Protein degradation. Chaperone-mediated autophagy 
UnknownObesity changes the human gut mycobiome.
Not available
S-EPMC4600977 | biostudies-literature
UnknownInformation flow, cell types and stereotypy in a full olfactory connectome.
Not available
S-EPMC8298098 | biostudies-literature
ProteomicsSenescent cells display an altered immunopeptidome and promote CD8-dependent antitumor immunity
Cellular senescence is a stress response known to activate innate immunity. However, how senescent cells interact with the adaptive immune system remains largely unexplored. Here, we show that senescent cells display an enhanced MHC class I antigen processing and presentation. Furthermore, senescent...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-10-18 | PXD033714 | Pride
Senescence Plasma membrane 
UnknownPreexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Not available
S-EPMC3079639 | biostudies-literature
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
UnknownHeterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up.
Not available
S-EPMC9072306 | biostudies-literature
UnknownMitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset.
Not available
S-EPMC6531455 | biostudies-literature
UnknownIdentification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.
Not available
S-EPMC7851759 | biostudies-literature
UnknownIncidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study.
Not available
S-EPMC8268420 | biostudies-literature
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