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ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053788 | Pride
Tgm2 Bidirectionally controls h3 monoaminylation dynamics Which Facilitate neural rhythmicity. In turn A single enzyme 
GenomicsChIP-seq of H3K4me3 and H3K27me3 histone marks in the hypothalamus of 35 days-old control and thermally-manipulated chickens
The experiment aimed at investigating the profiles of two histone marks (H3K27me3 and H3K4me3) in hypothalamus tissues of 35 days-old control (n=3) and thermally-manipulated (cyclic rise in egg incubation temperature of 1.5°C from days 7 to 16 of embryogenesis; n=3) chickens.
ORGANISM(S): Gallus gallus 
2019-10-31 | E-MTAB-7300 | biostudies-arrayexpress
TranscriptomicsKc167 ORC2 Localization
modENCODE_submission_674 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We will precisely identify sequence elements that direct DNA replication by using chromatin immunoprecipitation of known r...
ORGANISM(S): Drosophila melanogaster 
2010-05-15 | E-GEOD-17282 | biostudies-arrayexpress
TranscriptomicsKc167 Replication Timing
modENCODE_submission_668 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The relative time of replication for all unique sequences in the Drosophila genome was determined by synchronizing tissue ...
ORGANISM(S): Drosophila melanogaster 
2009-07-29 | E-GEOD-17279 | biostudies-arrayexpress
TranscriptomicsKc167 Replication Origins
modENCODE_submission_709 This submission comes from a modENCODE project of David MacAlpine. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: Early origins of replication were identified by treating cells with hydroxyurea (HU), a potent inhibitor of nucleotide syn...
ORGANISM(S): Drosophila melanogaster 
2010-05-15 | E-GEOD-17285 | biostudies-arrayexpress
ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053429 | Pride
Tgm2 Serotonylation Neural rhythmicity Histone h3 
GenomicsIdentification of Hnf6 binding sites in male and female mouse liver
∼40,000 HNF6 binding sites were identified in mouse liver chromatin, including several thousand sites showing significant differences in level of HNF6 binding between male and female mouse liver. These sex-biased HNF6 binding sites showed strong enrichment for sex-biased DNase hypersensitive sites a...
ORGANISM(S): Mus musculus 
2015-07-28 | E-GEOD-60014 | biostudies-arrayexpress
GenomicsHoxc9 ChIP-seq in differentiating motor neurons
The expression of v5-tagged Hoxc9 is induced and ChIP-seq is used to profile genome-wide occupancy in differentiating motor neurons The differentiation of ventral motor neurons is induced by treating embryonic stem cell cultures with retinoic acid and hedgehog signaling. Here, ChIP-seq is used to pr...
ORGANISM(S): Mus musculus 
2010-09-08 | E-GEOD-21812 | biostudies-arrayexpress
UnknownBidirectional histone monoaminylation dynamics regulate neural rhythmicity.
Not available
S-EPMC11754111 | biostudies-literature
TranscriptomicsHigh-resolution copy number analysis of medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genome of 212 medulloblastomas, a malignant pediatric brain tumor. Focal amplifications of fifteen known oncogenes and focal deletions of twenty known tumor suppressor genes (TSG) were revealed, most not prev...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress
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