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TranscriptomicsLong noncoding RNA expression during human B-cell development
Long noncoding RNAs (lncRNAs) have emerged as important regulators of diverse cellular processes, but their roles in the developing immune system are poorly understood. In this study, we analysed lncRNA expression during human B-cell development by array-based expression profiling of eleven distinct...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-69033 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of normal B-cell subsets from sternal bone marrow
Mononuclear cells were isolated from the sternal bone marrow and prepared for multiparametric flow cytometry using an optimized and validated protocol. B-cell subsets of PreBI, PreBII, Immature, Naive, Memory and Plasma cells were isolated and a al of 38 gene expression profiles were generated using...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-68878 | biostudies-arrayexpress
TranscriptomicsS mansoni infection B cell comparison
The helminth Schistosoma Mansoni is known to generate a regulatory B cell population that can suppress in multiple murine experimental models. Microarray comparison allows for a greater understanding as to how these cells are generated and their implications in immune regulation.
ORGANISM(S): Mus musculus 
2014-03-28 | E-MTAB-2100 | biostudies-arrayexpress
ProteomicsThe proteome of B cell maturation identifies PDCD4 as limiting the response of marginal zone B cells – WT and PDCD4 KO MZ B cells. Includes Fasta file
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-29 | PXD043351 | Pride
B cells Pdcd4 
ProteomicsThe proteome of B cell maturation identifies PDCD4 as limiting the response of marginal zone B cells – B cell subsets. Includes Fasta file.
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-29 | PXD043349 | Pride
B cells Pdcd4 
TranscriptomicsRecurrent 11q aberrations in MYC-neg mature aggressive B-cell lymphomas resembling BL
Copy number analysis using Agilent 244k or 180k (Case9) arrays was performed for 8 MYC-negative B-cell lymphomas, with sex-matched control DNAs Agilent 244k (cases 4-7 and 10-12) and 180k (Case9) arrays
ORGANISM(S): Homo sapiens 
2014-01-10 | E-GEOD-47506 | biostudies-arrayexpress
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
TranscriptomicsThe gene encoding the hematopoietic stem cell regulator CCN3 (NOV) is under direct cytokine control through the transcription factors STAT5a/b.
Cytokines control the biology of hematopoietic stem and progenitor cells in part through the transcription factors STAT5a/b. CCN3/NOV has been reported as a positive regulator of hematopoietic stem and progenitor cells. We report microarray analyses of Lineage- Sca-1+ c-Kit+ (KSL) cells in the pre...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20684 | biostudies-arrayexpress
ProteomicsBiogenesis of hepatitis B virus e antigen is driven by translocon-associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence
Hepatitis B virus (HBV) uses e antigen (HBe) which is dispensable for virus infectivity to modulate host immune responses and to achieve viral persistence in human hepatocytes. The HBe precursor (p25) is directed to the endoplasmic reticulum (ER), where cleavage of the signal peptide (sp) gives rise...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2022-07-01 | PXD025430 | Pride
Hbe Er translocation Hepatitis b virus Hbv precore protein Trap complex Signal peptide Cysteine residues 
ProteomicsThe proteome of B cell maturation identifies PDCD4 as limiting the response of marginal zone B cells
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-21 | PXD027054 | Pride
B cells B cell maturation 
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