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MetabolomicsChlorophyll biosynthesis under the control of arginine metabolism.

In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen sources, a growth-limiting factor. For acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments, as well as of the amino acid arginine, is ...

2024-03-12 | MTBLS8336 | MetaboLights
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
ProteomicsDe-novo synthesized targets of NMD and ER stress
Nonsense-mediated mRNA decay (NMD) has originally been described as a surveillance mechanism to inhibit the expression of mRNAs with truncated open reading frames (ORFs) and to contribute to the fidelity of gene expression. It is now recognized that NMD also controls the expression of physiological ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD002648 | Pride
Upr Aha Nmd Dtt Click chemistry Upf1 Pulsed silac 
UnknownStructure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.
Not available
S-EPMC7187165 | biostudies-literature
TranscriptomicsComplexity of expression from transiently transfected plasmids
Transient plasmid transfection is common approach for studies in cultured mammalian cells. To examine behavior of transfected plasmids, we analyzed their transcriptional landscape by deep sequencing. We found that plasmids generate different levels of transcripts virtually everywhere. Spurious trans...
ORGANISM(S): Homo sapiens 
2012-08-17 | E-GEOD-36062 | biostudies-arrayexpress
ProteomicsImidacloprid increases the prevalence of Lotmaria passim in honey bee workers
This dataset contains nanoLC-MS/MS results of heads of honey bee workers. All the heads were from 13 days old bees that were 11 days postinfection (DPI) that lasted 24 hours. Abdomens of bees were analyzed using qPCR to determine parasite load. Further, corresponding selected heads were subjected to...
ORGANISM(S): Lotmaria Passim (ncbitaxon:1620387) Apis Mellifera (ncbitaxon:7460) 
MSV000092818 | MassIVE
ProteomicsA thylakoid biogenesis BtpA protein is required for the initial step of tetrapyrrole biosynthesis in cyanobacteria
Biogenesis of the photosynthetic apparatus requires complicated molecular machinery, individual components of which are either poorly characterized or unknown. The BtpA protein has been described as a factor required for the stability of Photosystem I (PSI) in cyanobacteria; however, how the BtpA st...
ORGANISM(S): Synechocystis Sp. Pcc 6803 (ncbitaxon:1148) 
2023-07-13 | MSV000092431 | MassIVE
TranscriptomicsMicroarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma
With the increasing demand for non-invasive approaches in monitoring of head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of HNSCC patients in comparison to healthy individuals. We compared gene expression ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-MTAB-1516 | biostudies-arrayexpress
MetabolomicsAspSnFR: A Genetically-Encoded Biosensor for Real-Time Monitoring of Aspartate in Live Cells

Aspartate is crucial for nucleotide synthesis, ammonia detoxification and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate concentrations in real time and in live cells. We intr...

2024-08-27 | MTBLS10035 | MetaboLights
ProteomicsChlorophyll biosynthesis under the control of arginine metabolism
In natural environments, photosynthetic organisms adjust their metabolism to cope with the fluctuating availability of combined nitrogen-sources, a growth limiting factor. For the acclimation, the dynamic degradation/synthesis of tetrapyrrolic pigments as well as of the amino acid arginine is pivota...
ORGANISM(S): Synechocystis Sp. Pcc 6803 (ncbitaxon:1148) 
2023-02-14 | MSV000091280 | MassIVE
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