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Proteomics(Phospho-)proteomics analysis of fission yeast cells during mating and cell-cell fusion
In fission yeast Schizosaccharomyces pombe, sexual reproduction is triggered by the absence of nitrogen (N), and relies on crosstalk between multiple signaling pathways, with the inactivation of the TORC1 complex playing a critical role. This process is further elicited by pheromone signaling betwee...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2024-12-06 | PXD056619 | Pride
Sexual differentiation Yeast Nitrogen starvation Schizosaccharomyces pombe Cell-cell fusion 
ProteomicsNegative feedback regulation of the hemi-arrestin MAPK scaffold Sms1 prevents untimely mating
Mitogen-activated protein kinases (MAPK) are ancestral kinases that form essential signalling cascades. However, scaffolds that recruit kinases to subcellular locations and promote signal transduction have only been described in few species. Notably, no scaffold was thought necessary for the MAPK c...
ORGANISM(S): Schizosaccharomyces pombe 
2026-02-19 | PXD068764 | Pride
Convergent evolution Yeast schizosaccharomyces pombe Mitogen-activated protein kinase (mapk) Negative feedback Mapk scaffold 
ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
MetabolomicsLinking root exudates to functional plant traits
Primary and secondary metabolites exuded by plant roots have mainly been studied under laboratory conditions, while knowledge of root exudate patterns of plants growing in natural communities is very limited. Focusing on ten common European grassland plant species, we asked to which degree exuded me...
2022-02-11 | MTBLS687 | MetaboLights
UnknownDiffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis.
Not available
S-EPMC4397280 | biostudies-literature
MetabolomicsUntargeted Metabolite Profiling (LC-MS) of Root Exudates of Grassland Species

Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous influences. So far, root exudates have only been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated...

2020-06-18 | MTBLS865 | MetaboLights
MetabolomicsSemi‐polar root exudates in natural grassland communities
In the rhizosphere, plants are exposed to a multitude of different biotic and abiotic factors, to which they respond by exuding a wide range of secondary root metabolites. So far, it has been unknown to which degree root exudate composition is species-specific and is affected by land use, the local ...
2018-08-15 | MTBLS671 | MetaboLights
ProteomicsA Biomarker Panel for Chronic Graft-versus-Host Disease
Using a quantitative proteomics approach, we compared pooled plasma samples from 35 patients with cGVHD obtained at a median of 103 days post-HCT and 18 patients without cGVHD obtained at matched timepoints to identify biomarkers for cGVHD.
ORGANISM(S): Homo sapiens (Human) 
2016-05-27 | PXD002762 | Pride
Cgvhd Biomarker 
TranscriptomicsComparative gene expression in the human limbus, conjunctiva and cornea
To date, there is no specific marker for limbal epithelial stem cells. The identification of a marker that is expressed in the limbal epithelium but not in the cornea or conjunctiva epithelium has been a growing need. To search for limbal-specific marker(s), we performed preferential gene profiling ...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-38190 | biostudies-arrayexpress
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
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