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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
UnknownFalling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition.
Not available
S-EPMC2247379 | biostudies-literature
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
TranscriptomicsRNA-seq of Arabidopsis response to Tetranychus urticae infestation
The Arabidopsis/Tetranychus urticae pair is a model to analyze the response of the plant to the infestation with phytophagous acari. To deep into the short-term response of the plant, a time series was performed starting upon 30 min of infestation. Additional time points at 1h, 3h and 24h were selec...
ORGANISM(S): Arabidopsis thaliana 
2021-03-16 | E-MTAB-9448 | biostudies-arrayexpress
ProteomicsDissection of prognostic traits in colorectal cancer using multi-dimensional proteomics
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and the second leading cause of cancer death globally. The molecular mechanisms underlying CRC have been investigated using different omics technologies including genomics, proteomics, and metabolomics. Resulting molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-03-26 | PXD044246 | Pride
Proteomics Colorectal cancer Phosphoproteomics 
UnknownAssociation between Changes in the Patterns of Antinuclear Autoantibodies during Immune Checkpoint Inhibition Therapy and the Development of Severe Immune Related Adverse Events
Not available
S-EPMC9604501 | biostudies-literature
ProteomicsMitochondrial reprogramming underlies resistance to BCL-2 inhibition in lymphoid malignancies
Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez A, Sun J, Baranowski K, Thompson PA, Heo J, Cartun Z, Aygun O, Notarangelo G, Livitz D, Li S, Hacken ET, Davids MS, Iorgelescu JB, Zhang W, Biran A, Fernandes SM, Brown JR, Ana Lako A, Ciantra ZB, Keskin DB, Udeshi ND, Wierd...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-02 | MSV000083512 | MassIVE
TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
UnknownEffect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial.
Not available
S-EPMC7825875 | biostudies-literature
ProteomicsON THE ACCURACY, PRECISION AND STATISTICAL SIGNIFICANCE OF COMPRESSED RATIOS IN ISOBARIC LABELLING
Despite the outstanding advantages that isobaric labelling has to offer in quantitative proteomics, its precision and accuracy are undermined by ratio compression, which is consequence of the co-isolation of peptides within a selected isolation window. Here, using the two-proteomes approach we inves...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2016-08-08 | PXD003640 | Pride
Isobaric labelling Statistics Accuracy Ratio compression Precision 
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