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Characterisation of AEP physiological targets using specific inhibitors and TurboID approaches
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053016 | Pride
Programmed cell death is an event displayed by many different organisms along the evolutionary scale. In plants, it is necessary for development and for the hypersensitive response to stress or pathogenic infection. A common feature to programmed cell death among organisms is the mitochondria-to-cyt...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2013-11-11 | PXD000280 | Pride
Cytokines are highly pleiotropic ligands that critically contribute to a balanced immune response. We have an incomplete understanding of how cytokines elicit their functional pleiotropy, which has limited their therapeutic efficacy. Here, using Interleukin-6 (IL-6) as a model system, we have perfor...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020964 | Pride
Understanding the regulation of lysosomal proteolytic/hidrolytic capacity has been recently advanced in a huge manner by the discovery of the lysosome-mTOR-TFEB pathway connecting nutrient sensing, autophagy and de novo lysosome generation. But, how lysosomes can adjust their proteolytic/hidrolytic ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-09 | PXD011473 | Pride
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