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ProteomicsA single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes
The UVB component of the sunlight (290-320 nm) plays an important role in carcinogenesis through generation of high levels of bipyrimidine DNA photoproducts, while UVA (320-400 nm) has been associated with photoaging and tumor progression through generation of low, but continuous levels of DNA damag...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025191 | Pride
Orbitrap fusion lumos Keratinocytes Hacat Nhek Uva light Shotgun Senescence 
ProteomicsSpatial proteomics reveals profound subcellular reorganization in human keratinocytes exposed to UVA light
The effects of UV light on the skin have been extensively investigated. However, systematic information about how exposure to UVA light, the least energetic but the most abundant UV radiation reaching the Earth, shapes the subcellular organization of proteins is lacking. Using subcellular fractionat...
ORGANISM(S): Homo sapiens (Human) 
2022-03-06 | PXD027941 | Pride
Spatial proteomics Keratinocytes Uva light 
ProteomicsProteomic Profiling of Retinoblastoma-Derived Exosomes reveals potential biomarkers of vitreous seeding
Retinoblastoma (RB) is the most common tumor of the eye in early childhood. Despite recent advances in conservative treatment have greatly improved the visual outcome, local tumor control remain difficult in presence of massive vitreous seeding. Traditional biopsy has long been considered unsafe in ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016488 | Pride
Exosomes Proteomics Retinoblastoma Biomarkers 
UnknownProteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding.
Not available
S-EPMC7352325 | biostudies-literature
UnknownNeuroblastoma-secreted exosomes carrying miR-375 promote osteogenic differentiation of bone-marrow mesenchymal stromal cells.
Not available
S-EPMC7448845 | biostudies-literature
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