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ProteomicsProMetheus: a database of hmSILAC-validated protein methylation sites
Protein arginine (R) methylation is a post-translational modification that has been shown to play a role in various biological processes, such as RNA splicing, DNA repair, immune response, signal transduction and tumor development. Here, we present a dataset of high-quality methylations obtained fro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD027949 | Pride
Heavy methyl silac Silac Methylation 
ProteomicsSystematic analysis of the impact of R-methylation on RBPs-RNA interactions
RNA binding proteins (RBPs) bind RNAs through specific RNA-binding domains, generating multi-molecular complexes known as ribonucleoproteins (RNPs). Various post-translational modifications (PTMs) have been described to regulate RBP structure, subcellular localization and interactions with other pro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD024601 | Pride
Prmts Oops R-methylation Rbps 
ProteomicsTherapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation
Cancer-associated mutations in RNA splicing factors commonly occur in myeloid and lymphoid leukemias as well as a variety of solid tumors and confer dependence on wild-type (WT) splicing. These observations have led to clinical efforts to directly inhibit the spliceosome in patients with refractory ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-30 | PXD012007 | Pride
Prmt1 Prmt5 Leukemia Methylation 
ProteomicsTargeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for Retinoic Acid induced differentiation
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells through degradation of the PML-R...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012954 | Pride
Lsd1 inhibitors Lsd1 Acute myeloid leukemia Protein-protein interaction 
ProteomicsLSD1 interactome in Glioblastoma
Tumor-initiating cells (TICs) play a critical role in glioblastoma (GBM) maintenance being responsible for its heterogeneity and resistance to standard therapy. A step toward clinical translation includes GBM TIC targeting. Among the molecules tested for GBM treatment, are those targeting epigeneti...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD021429 | Pride
Glioblastoma Lsd1 Protein complex Lsd1 inhibitor Targeted therapy 
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