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MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - Smartseq 2 data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. This part contains RN...
ORGANISM(S): Homo sapiens 
2019-08-21 | E-MTAB-6678 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - whole genome sequencing
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. Demuxlet was used to ...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7304 | biostudies-arrayexpress
TranscriptomicsReconstructing the human first trimester fetal-maternal interface using single cell transcriptomics - 10x data
To explore the interactions between the range of maternal and fetal placental cell types present, we profiled the transcriptomes of more than 50,000 single cells from matched first trimester samples of maternal blood and decidua, as well as fetal cells from the placenta itself. RNA-seq was done usin...
ORGANISM(S): Homo sapiens 
2018-10-02 | E-MTAB-6701 | biostudies-arrayexpress
GenomicsSexually dimorphic crosstalk at the maternal-fetal interface
Sexually dimorphic crosstalk at the maternal-fetal interface
PRJNA545159 | ENA
UnknownExtracellular vesicles from maternal uterine cells exposed to risk factors cause fetal inflammatory response.
Not available
S-EPMC8499538 | biostudies-literature
GenomicsSexually dimorphic crosstalk at the maternal-fetal interface
Sexually dimorphic crosstalk at the maternal-fetal interface
PRJNA544522 | ENA
TranscriptomicsObesogenic diet disrupts endometrial stromal cell differentiation in the E5.5 mouse uterus
Maternal obesity is associated with increased risk of infertility, implantation failure, miscarriage, and other pregnancy complications. While prior studies have linked obesity to uterine dysfunction and impaired endometrial biology, how obesity alters the cellular and molecular landscape of the ear...
ORGANISM(S): Mus musculus 
2026-08-03 | E-MTAB-16176 | biostudies-arrayexpress
UnknownExploratory Urinary Proteomic Profiling in Pregnancies with Fetal Aneuploidies: Molecular Insights into Maternal-Fetal Metabolic Communication.
Not available
S-EPMC12731864 | biostudies-literature
TranscriptomicsSexually dimorphic crosstalk at the maternal-fetal interface
The first trimester is a critical window of maternal-fetal communication for pregnancy. RNA-sequencing of matched maternal decidua (4) and placenta (4) identified 91 sexually dimorphic receptor-ligand pairs across the maternal-fetal interface, 32 in females and 59 in males.
ORGANISM(S): Homo sapiens 
2020-08-20 | GSE131874 | GEO
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