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Mathematical modelling reveals a ribosome level-induced survival checkpoint in drug-tolerant cancer persister cells
Systemic treatments for advanced cancers initially provide benefits but rarely lead to a cure due to acquired resistance. Drug-tolerant persister (DTP) cells, devoid of new mutations, can temporarily tolerate treatment. In previous study, we observed that melanoma DTP cells downregulated mRNA transl...
ORGANISM(S): Homo sapiens Mus musculus 
2026-03-15 | GSE313946 | GEO
Dual β-lactam therapy for high-risk P. aeruginosa ST235 clone clinical isolates, investigated through in hollow-fibre infection models, next generation mechanism-based mathematical modelling and population genomics
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