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ProteomicsDeamidation in human islets of Langerhans
The β-cell plays a central role in the pathogenesis of T1D by neoantigen formation due to the generation of post-translational modifications, such as deamidation, being potential triggers for breaking immune tolerance. We report the detection by LC-MS/MS of 16 novel Gln and 27 novel Asn deamidations...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD038758 | Pride
Human Pancreas Islets of langerhans 
ProteomicsAberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.
Post-translational modifications can lead to a break in immune tolerance in autoimmune diseases such as type 1 diabetes (T1D). Deamidation, the conversion of glutamine to glutamic acid by transglutaminase (TGM) enzymes, is a post-translational modification of interest, with deamidated peptides being...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-21 | PXD034102 | Pride
Type 1 diabetes Post-translational modification Transglutaminase 2 Deamidation 
ProteomicsNET proteome of neutrophils from people with long-standing type 1 diabetes and healthy control
Type 1 diabetes (T1D) is a chronic T-cell-mediated autoimmune disease, leading to the destruction of the pancreatic insulin-producing beta cells. Little is known about the involvement of neutrophils that exert multifaceted functions like phagocytosis, degranulation, production of cytokines and the f...
ORGANISM(S): Homo sapiens (Human) 
2023-05-15 | PXD033599 | Pride
Human Lc-msms Netosis Neutrophils Type 1 diabetes 
TranscriptomicsTranscription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog
Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin ...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-23984 | biostudies-arrayexpress
UnknownEffect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study.
Not available
S-EPMC11056389 | biostudies-literature
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