Sort   by:  
 Page size 
TranscriptomicsGene expression profile of conventional T cells (Tconv) and regulatory T cells (Treg) stimulated with anti-costimulatory molecule antibodies
Co-stimulatory molecules of the CD28 family on T lymphocytes integrate cues from innate immune system sensors, and modulate activation responses in conventional CD4+ T cells (Tconv) and their FoxP3+ regulatory counterparts (Treg). To better understand how costimulatory and co-inhibitory signals migh...
ORGANISM(S): Mus musculus 
2012-11-15 | E-GEOD-42276 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsRapid, high efficiency isolation of pancreatic ß-cells
The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed an exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional pancreatic ß-cells. By targeting the glucagon-like peptide-1 receptor, ß-cells were isolate...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-64508 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse RTOC cell cultures
Four independent chip hybridization with RNAs from four independent RTOC cultures.
ORGANISM(S): Mus musculus 
2007-11-08 | E-GEOD-1112 | biostudies-arrayexpress
TranscriptomicsNaturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice
Vertebrates typically harbor a rich gastrointestinal microbiota, which has co-evolved with the host over millennia and is essential for several of its physiological functions, in particular maturation of the immune system. Recent studies have highlighted the importance of a single bacterial species,...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29806 | biostudies-arrayexpress
TranscriptomicsDeficiency of CXCR2, but Not Other Chemokine Receptors, Attenuates Autoantibody-Mediated Arthritis in a Murine Model
To examine patterns of gene expression in ankle synovial fluid cells and peripheral blood leukocytes during serum transferred arthritis. A time-course microarray analysis of serum-transferred arthritis was performed, examining ankle tissue, synovial fluid, and peripheral blood leukocytes.
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-27492 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymphtoxin beta receptor-deficient thymic medullary epithelial cells vs. wild-type and Aire-deficient vs wild-type littermates
We compared gene expression profiles of lymphotoxin alpha- and lymphtoxin beta receptor-deficient thymic medullary epithelial cells with their wild-type littermates, as well as with Aire-deficient and wild-type littermates. This was done in order to determine whether there was overlap in the effects...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8563 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of CD4+CD25+ Tregs from NOD and B6.H2g7 mice
The NOD (nonobese diabetic) mouse strain develops a characteristic autoimmune syndrome that closely resembles human type I diabetes. It has been suggested that NOD mice exhibit both numerical deficiency in CD4+CD25+ regulatory T cells (Treg) and reduced suppressive activity. We compared sorted CD4...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-6813 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice
Comparison of gene expression between T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice. WARNING: These data files were obtained from GSM155557.CEL and GSM23405.CEL may be identical.
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1419 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse OTI CD8 T cells transferred to irradiated syngeneic hosts
A time course of OTI CD8 T cells transferred to irradiated syngeneic hosts (or unirradiated hosts as control).
ORGANISM(S): Mus musculus 
2007-11-02 | E-GEOD-1921 | biostudies-arrayexpress
Sort   by:  
 Page size